Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New gene chip may be early cancer diagnosis tool

20.06.2005


A pilot study at the National Institute of Standards and Technology (NIST), in support of the National Cancer Institute’s Early Detection Research Network (EDRN), has validated the measurement accuracy of new techniques that use mitochondrial DNA as an early indicator for certain types of cancer. Additional results suggest that a relatively simple diagnostic test using a DNA microarray "chip" could enable early detection of some solid tumors, including lung cancer.



Mitochondrial DNA (mtDNA) plays a role in respiration and the cell’s energy conversion mechanism. Since the late 1990s, researchers at the Johns Hopkins University School of Medicine have observed changes in mtDNA sequences in solid cancers, although the nature of the relationship remains uncertain. Their work suggested that particular changes in mtDNA might serve as early indicators for several types of solid cancer. Although promising, this approach is critically dependent on developing reliable, cost-effective, and highly sensitive methods of analysis to detect the cancer indicators against the background of natural variation in mtDNA.

The NIST Cancer Biomarker Validation and Reference Laboratory assesses cost, efficiency and reliability of potential diagnostic techniques using biomarkers before further clinical evaluation in other laboratories of the EDRN. The lab found that full mitochondrial genome sequencing using capillary electrophoresis detected mtDNA changes associated with early cancer. In ongoing work, NIST is comparing capillary electrophoresis methods with a newly developed DNA sequencing chip. The mtDNA chips are a promising research tool for early clinical cancer diagnosis that may be faster, easier to interpret, and provide higher throughput than other methods. A paper describing the NCI-NIST work appears in the May issue of the Journal of Molecular Diagnostics.*


Funded and coordinated by the National Cancer Institute to speed the development of molecular, genetic and other biomarkers for early cancer detection, the Early Detection Research Network is a national network of research institutions, including developmental labs, validation labs and clinical centers. NIST is one of five reference and validation labs in the EDRN.

*J.P. Jakupciak, W.Wang, M.E. Markowitz, D. Ally, M. Coble, S. Srivastava, A. Maitra, P.E. Barker, D. Sidransky, and C.D. O’Connell. Mitochondrial DNA as a Cancer Biomarker. Journal of Molecular Diagnostics 2005 7: 258-267.

Michael Baum | EurekAlert!
Further information:
http://www.nist.gov

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Optical Coherence Tomography: German-Japanese Research Alliance hosted Medical Imaging Conference

19.11.2018 | Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

 
Latest News

New materials: Growing polymer pelts

19.11.2018 | Materials Sciences

Earthquake researchers finalists for supercomputing prize

19.11.2018 | Information Technology

Controlling organ growth with light

19.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>