Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Shorter course of radiotherapy effective for palliation of painful bone metastases

01.06.2005


A single treatment of 8 gray (Gy--a unit of measure of absorbed radiation dose) of radiation appears to be as effective in palliating painful bone metastases as the current U.S. standard treatment course of 30 Gy delivered in 10 daily treatments, according to a new study in the June 1 issue of the Journal of the National Cancer Institute.



Patients with a variety of solid tumor cancers, including lung, breast, and prostate, can develop painful metastases in the bones of the spine, pelvis, and extremities. Although the standard treatment, radiation therapy delivered in 10 daily sessions, is effective in providing relief--50% to 80% of patients experience improvement in their pain, and 20% to 50% have complete pain relief--a shorter course of treatment would be easier for patients and their families to arrange and would also have less impact on the timing of other treatments.

To determine whether a shorter course of radiation is equivalent to the standard treatment, William F. Hartsell, M.D., of Lutheran General Cancer Center in Park Ridge, Ill., and colleagues randomly assigned nearly 900 patients with breast or prostate cancer who had one to three sites of painful bone metastases to receive either 8 Gy of radiation in one treatment session or 30 Gy of radiation in 10 daily treatment sessions.


As assessed at three months after treatment, both regimens provided equivalent pain relief, and an equivalent proportion of patients no longer required narcotic medication. There was a higher rate of re-treatment but less acute toxicity in the group that received only one course of 8 Gy radiation compared with the 30-Gy group.

"Further analysis of data from [this] trial should yield important information on quality of life, health utilities (i.e., patient preferences for specific health states or treatments), and economic end points. These data will help determine whether a single dose of 8 Gy should become the standard treatment for palliation of localized painful bone metastases," they write.

In an editorial, Lisa Kachnic, M.D., of Boston University Medical Center, and Lawrence Berk, M.D., Ph.D., of Central Ohio Radiation Oncology in Columbus, discuss other trials that have addressed the use of short-course radiation for the palliation of bone metastases. "[T]hree very large randomized trials … have all demonstrated that single-fraction radiation therapy is sufficient to achieve palliation of painful bone metastases," they write. "It remains to be seen if this approach will become standard of care in the United States. The outcome may distinguish whether radiation oncologists in the United States practice evidence-based or remuneration-based medicine."

Sarah L. Zielinski | EurekAlert!
Further information:
http://www.oupjournals.org

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>