Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New drug delivery research holds promise for osteoporosis sufferers

31.05.2005


Calcitonin, a hormone that lowers calcium levels in the blood and prevents bone loss, has only been available in an injectable and nasally-administered format to date. New research by Conway investigator, Dr David Brayden promises to ultimately deliver an oral method of treating osteoporosis patients with this hormone, which would have many advantages over current treatment regimes.



All drugs taken orally face the same problem; they must get from the gut into the bloodstream and avoid being broken down by enzymes before they can carry out their job. This is no mean task for many drugs, but it is especially problematic for peptides, some of the main products of the pharmaceutical industry. Dr David Brayden, who is based in the Faculty of Veterinary Medicine, University College Dublin has suggested a method for delivering calcitonin into the bloodstream by the oral route. The research involves attaching calcitonin to a novel sticky polymer and incorporating components that will both prevent the breakdown of calcitonin and help it move across the gut wall.

Science Foundation Ireland recently awarded Dr Brayden substantial funding under their investigator programme grant scheme to develop his research. Dr. Brayden was formerly a senior research scientist with Elan Corporation before moving to University College Dublin in 2001.


He will collaborate with Professor David Haddleton, University of Warwick, on the project. Professor Haddleton is a conjugate polymer chemist who received the 2004 Chemistry World Entrepreneur of the Year as a result of the setting up of his company, Warwick Effect Polymers.

Their combined expertise will enable them to create an oral formulation of calcitonin that may eventually lead to production of a tablet, assuming that the drug can still work in its new format. Dr Brayden will develop cell culture, tissue and in vivo models to assess the effectiveness of this new drug delivery system. Commenting on the programme, Dr Brayden said ‘attaching drugs to new polymers may pave the way for new oral treatments of osteoporosis and of several other diseases where injections are the usual choice’.

Elaine Quinn | alfa
Further information:
http://www.ucd.ie/conway

More articles from Health and Medicine:

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Massive impact crater from a kilometer-wide iron meteorite discovered in Greenland

15.11.2018 | Earth Sciences

When electric fields make spins swirl

15.11.2018 | Physics and Astronomy

Discovery of a cool super-Earth

15.11.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>