A new type of drug originally developed for lung cancer can reduce the size of breast cancer tumours when taken in combination with other drugs. A London-based group of scientists, reporting today (Tuesday 17 May) in The Lancet Oncology, say that taking the new drug combination prior to surgery could make breast cancer surgery less invasive and more effective, and reduce the risk of cancer spreading to other parts of the body.
Around 80% of breast cancers depend on the hormone oestrogen to survive, and removing oestrogen from the body is standard treatment for the disease. However, only half of primary breast cancers respond well to this therapy, leading doctors to use more toxic chemotherapy, which causes many side effects. The researchers have found that by combining existing oestrogen-blocking drugs with a new drug called gefitinib that blocks another receptor on the cancer cell surface, tumour growths shrink more rapidly and to a smaller size.
The study followed 56 post-menopausal women who had cancer cells with oestrogen receptors (ER) and epidermal growth factor receptors (EGFR). Half received the oestrogen-blocker anastrozole and the EGFR-blocker gefitinib, the other half received gefitinib and a placebo. Treatment was for 4-6 weeks, prior to surgery to remove the cancer.
Simon Wilde | alfa
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
15.08.2018 | Physics and Astronomy
15.08.2018 | Earth Sciences
15.08.2018 | Physics and Astronomy