Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New prognostic markers help identify risk of relapse

28.04.2005


A recently completed clinical study has found new prognostic markers that may help clinicians identify those children with leukaemia who are at high risk of relapse and are most in need of intensified treatment to improve their chance of survival.



The retrospective clinical study, performed jointly by the Centre for Children’s Cancer and Blood Disorders (CCC&BD)at Sydney Children’s Hospital and Children’s Cancer Institute Australia, was recently published in the international Journal of Clinical Oncology. Researchers investigated how both normal and malignant blood cells of children with Acute Lymphoblastic Leukaemia (ALL) responded to the first phase of chemotherapy treatment (induction).

Dr Stephen Laughton and co-investigators found that a slow rate of recovery of normal white blood cells at the end of induction, as shown by a low absolute neutrophil count (ANC), was highly predictive of relapse.


"Many traditional predictive factors have lost their significance over time, so there is a real need to find new markers that can be used to identify high-risk patients," said A/Prof Glenn Marshall, Director of the CCC&BD and Head of the Molecular Carcinogenesis Program at CCIA.

"Our work is the first to highlight the fact that the differences in the responses of normal and malignant blood cells may vary between individuals, and, moreover, that this information might be used to adjust therapy on an individual basis."

The study also found, as investigators expected, that high levels of leukaemic cells surviving initial treatment, minimal residual disease (MRD), indicated a high risk of relapse. A technique to determine levels of MRD was pioneered at CCIA.

However, the two prognostic factors (low ANC and high MRD) were found to predict outcome by distinct mechanisms and to have independent prognostic significance.

"These results are very promising," says A/Prof Marshall. "If ANC levels can complement MRD levels at the end of induction in predicting relapse as our study indicates, it may help clinicians identify patients in need of more intensive therapy. At the same time it may be useful in identifying those children who could have reduced therapy and avoid drug side-effects."

The study’s authors recommend a prospective clinical trial now be undertaken to test the value of these findings for clinical practice.

Acute lymphoblastic leukaemia (ALL), the most common cancer in children, accounts for about 30% of all deaths from childhood cancer in Australia. While almost all children treated for ALL respond well initially, 20% will develop drug resistance and will relapse with reduced chance of recovery.

Susan Bogle | EurekAlert!
Further information:
http://www.ccia.org.au

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>