Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Faulty body clock leads to obesity and diabetes

22.04.2005


Obesity and diabetes in both adults and children are rising at alarming rates and a wide range of culprits -- super-sized food portions, lack of exercise due to television, computers, suburban sprawl and loss of gym classes, high-fat and fast foods, sugar-laden drinks and psychological trauma -- have been blamed.



Now researchers from Northwestern University and Evanston Northwestern Healthcare (ENH) have pinpointed something deep within the brain and other tissues that plays an important role in the struggle to maintain a healthy weight: the body’s 24-hour internal clock. The research team, led by an endocrinologist and a circadian rhythms expert, has shown that a faulty or misaligned body clock, which regulates both sleep and hunger, can wreak havoc on the body and its metabolism, increasing the propensity for obesity and diabetes.

The findings will be published online April 21 by the journal Science.


"Just as there is a mechanism that makes the heart beat, there is a clock that functions in many different parts of the body to regulate many different systems," said Joseph Bass, M.D., senior author and assistant professor of medicine and neurobiology and physiology at Northwestern and head of the division of endocrinology and metabolism at ENH.

"We don’t know too much about how clocks control eating and metabolism in normal individuals, but now we have shown that weight gain and abnormalities in metabolism, including diabetes, result if this internal timepiece is malfunctioning. The body clock is clearly controlling the elaborate brain signaling system that regulates appetite."

"We’ve demonstrated that an animal model with a known circadian disregulation -- a mouse with a mutant Clock gene and thus an imprecise body clock -- has metabolic problems, at least obesity and signs of the metabolic syndrome," said circadian rhythm expert Fred W. Turek, lead author on the paper and professor of neurobiology and physiology in Northwestern’s Weinberg College of Arts and Sciences.

"This provides new genetic evidence that physiologic outputs of the biological clock, sleep and appetite are interconnected at the molecular and behavioral levels, yielding implications on the role of internal biological timing in optimizing strategies to reduce and sustain weight loss resulting from both medical and lifestyle modifications."

The research team also includes Joseph S. Takahashi, Walter and Mary Elizabeth Glass Professor in the Life Sciences and a Howard Hughes Medical Institute investigator at Northwestern, who led the team that cloned the first mammalian circadian gene, Clock, in 1997. This discovery provided the genetic model critical to this study reported in Science.

The scientists exposed mice to regular and high-fat diets and compared the response of the mutant animals to the response of the normal animals. They discovered that the animals with the Clock mutation were unable to regulate their body weight in the presence of either diet. The effect of the Clock mutation on body weight in animals fed a regular diet was similar in magnitude to the effect of a high-fat diet in normal mice. When the Clock mutant animals were fed a high-fat diet, the combined effect of diet plus mutation led to the most severe alteration in body weight and changes in metabolism. The obese mice showed metabolic abnormalities in insulin secretion and the ability of the liver to handle sugar.

Obesity is associated with metabolic and cardiovascular disorders often referred to as the metabolic syndrome, which increases an individual’s risk of developing a serious disease, said Bass and Turek. In addition to excess body weight, factors include high blood pressure, high insulin levels and one or more abnormal cholesterol levels and, at the whole animal level, an inability to expend excess calories consumed. Robert H. Eckel, M.D., an author on the Science paper and professor of medicine at the University of Colorado at Denver and Health Sciences Center and president-elect of the American Heart Association, and his colleagues found the Clock mutant animals had reduced energy dissipation despite positive energy balance, compounding the obesity phenotype in these animals.

"Our findings lead to provocative questions that require further investigation," said Bass. "Is it possible that sleep loss or a change in circadian rhythms might exacerbate problems in regulating appetite? It may be a question of not only how much you eat but what time of day you eat and how that affects the body. Are you eating at a time of day when your system is internally aligned to metabolize the food?"

Approximately 18 million people in the United State have diabetes and nearly two-thirds of adults are overweight, which includes 30 percent who are obese. Together, diabetes and obesity result in almost 200,000 deaths annually and exert a devastating social and economic toll due to complications including blindness, kidney failure, heart disease and stroke.

Biological clocks function in the brain as well as lung, liver, heart and skeletal muscles. They operate on a 24-hour, circadian (Latin for "about a day") cycle that governs functions like sleeping and waking, rest and activity, fluid balance, body temperature, cardiac output, oxygen consumption and endocrine gland secretion.

"The body clock regulates the time we go to bed, the time we get up and the time we get hungry -- these are biological principles not psychological factors," said Bass. "This internal drive is a fundamental system that is important to health."

Megan Fellman | EurekAlert!
Further information:
http://www.northwestern.edu

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>