Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Mystery blood vessel disorder implicated in ’mini’ strokes

01.03.2005


Physicians have long been puzzled by a condition called intracranial arterial dolichoectasia, in which the larger arteries of the brain become elongated and misshapen. Typically, it has been considered a complication of atherosclerosis ("hardening of the arteries"), and not directly life-threatening. However, there is recent evidence that people with dolichoectasia are more likely to have aortic aneurysms, a potentially fatal weakening of the main artery that carries blood out from the heart. In an article published online February 28, 2005 in the Annals of Neurology the same French researchers who linked dolichoectasia with aortic aneurysm reveal new evidence that links the disorder with small vessel disease, a significant cause of lacunar or "mini" strokes that can damage small areas of the brain.

Depending on which area of the brain is affected, the strokes can impair functions such as movement, physical control of speech, or coordination. Multiple lacunar strokes can also cause cognitive and memory deficits that resemble Alzheimer’s disease.

According to the authors, physicians who encounter patients with small vessel disease should look for evidence of dolichoectasia. "If dolichoectasia is present, you should look for an associated abdominal aortic aneurysm and carefully search for associated cardiac symptoms," said author Pierre Amarenco, M.D., of Bichat University Hospital in Paris.



Beyond the immediate clinical implications, the study may offer more important clues for further research. It may be that dolichoectasia causes or contributes to small vessel disease, and/or that the two have common causes.

Nearly a quarter of all strokes arise from blood flow problems in the smallest blood vessels of the brain. Patients with the disease are usually found to have high blood pressure, but the causes of the disease are unknown.

Using MRI, Amarenco and his colleagues studied 510 patients who had suffered strokes and found that the subset of patients with dolichoectasia were more likely to have evidence of small vessel disease. Indeed, there was a direct relationship between the diameter of the basilar artery, the cranial artery most often affected in dolichoectasia, and the severity of small vessel disease.

"This study is the first to show an association between intracranial arterial dolichoectasia and the whole spectrum of small vessel disease abnormalities, thus defining a new cerebrovascular syndrome," said Amarenco.

The researchers will continue to follow the patients in this study (the GENIC study) to try to determine which vascular or genetic factors contribute to the syndrome. They will also attempt to replicate their MRI data in an autopsy study of patients who died with dolichoectasia.

David Greenberg | EurekAlert!
Further information:
http://www.interscience.wiley.com/journal/ana
http://www.wiley.com
http://www.aneuroa.org

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>