New biomolecular technologies have largely failed to deliver the hoped-for knockout punch breakthrough against the defences of disease-causing bacteria, says a leading Canadian specialist in antibiotic resistance.
Techniques such as genomic sequencing and high throughput screening were expected to make the development of new antibiotic compounds easier and more productive. But in most cases the microbes continue to hold the upper hand – and if three billion years of bacterial history is any kind of track record, were in for an endless running battle, says Dr. Julian Davies, a microbiologist at the University of British Columbia.
"We havent evolved in our thinking sufficiently to be able to match the microbes," says Dr. Davies, Scientific Director of the Canadian Bacterial Diseases Network. "Pharmaceutical companies and other researchers have put hundreds of millions of dollars into modern approaches to antibiotic discovery over the past six or seven years and this has failed miserably."
Dr. Julian Davies | EurekAlert!
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