A womans risk of ovarian cancer rises significantly if she carries either of two previously unexamined variations in the gene that codes for the progesterone receptor, according to a team of researchers led by scientists from the Keck School of Medicine of the University of Southern California.
The study, which is being published in the January 5th issue of the Journal of the National Cancer Institute, was initially supposed to be a more in-depth look at one particular version-or allele-of the progesterone receptor gene (PGR). The PROGINS allele, says Celeste Leigh Pearce, a preventive medicine researcher from the USC/Norris Comprehensive Cancer Center and the papers first author, had previously been linked to a higher ovarian cancer risk as well as a lower breast cancer risk in women who carry it.
To see if the PROGINS allele did indeed confer a higher ovarian cancer risk on women, the researchers-led by the studys principal investigator, USC preventive medicine professor Malcolm Pike-first used biological samples collected by the Hawaii/Los Angeles Multiethnic Cohort Study. (The Multiethnic Cohort is one of the largest ongoing population studies in the world, and is led by Brian E. Henderson, M.D., the Kenneth T. Norris Jr. Chair in Cancer Prevention and dean of the Keck School of Medicine.) The scientists examined the variety of genetic variations found in the PGR gene as part of a long-term collaboration between USC researchers and those at the Broad Institute in Cambridge, MA, looking to ascertain if the PROGINS allele held a particular risk of ovarian cancer for women.
Jon Weiner | EurekAlert!
UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego
New cancer immunotherapy approach turns immune cells into tiny anti-tumor drug factories
05.12.2018 | University of California - San Diego
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
06.12.2018 | Event News
03.12.2018 | Event News
28.11.2018 | Event News
07.12.2018 | Life Sciences
07.12.2018 | Materials Sciences
07.12.2018 | Physics and Astronomy