Bone marrow transplantation can cure lymphomas and leukemia, but in about half of the cases transplanted immune cells wind up attacking the patients body, as well as the cancer.
In response to this problem, researchers at the Stanford University School of Medicine have developed a technique that can virtually eliminate this life-threatening complication, known as graft-versus-host disease, without compromising the transplanted cells effectiveness against cancer.
The therapy entails adjusting the patients level of a specific type of immune cell, the regulatory T cells, before the transplant is done. The method was first developed in mice by Samuel Strober, MD, professor of medicine (immunology and rheumatology), who has been studying these types of cells for more than 25 years. Robert Lowsky, MD, assistant professor of medicine (bone marrow transplantation), has adapted this strategy for humans along with Strober, and will present the results of tests Dec. 6 at the annual American Society of Hematology meeting in San Diego.
M.A. Malone | EurekAlert!
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
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