Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Smoking habits during pregnancy may cause genetic instability in the foetus

01.12.2004


The Spanish Pediatrics Association has recently awarded the Pediatrics laboratory at the University of Navarre for a research into tobacco and foetal genetic instability. The study, by Marta Zalacaín, was carried out in conjunction with the Department of Gynacology and Obstetrics at the Hospital Virgen del Camino. “It involved analysing umbilical cords from many births which took place at both centres over three years and which have been distributed in four groups: non-smoking mothers, ex-smokers, those who stop smoking during pregnancy and those who continue to smoke. The aim was the look for any instability in the cord blood to see if there was any relationship with the smoking habits of the mother, either active or passive. In order to carry out this study, the collaboration by the Hospital Virgen del Camino has provided us with a very wide-ranging population of smoking mothers”, explains Marta Zalacaín. The research involved a questionnaire filled in by both the mother and father regarding their smoking habits, together with biochemical tests to measure cotinine in urine, the metabolite produced by nicotine in the body.



Micronuclei

This work involves the micronuclei testing, the technology of which has been developed and applied successfully by Marta Zalacaín. According to Dr. Patiño, “When a genotoxic agent affects the cells, such as benzoapyrene in tobacco, genetic damage may be caused which interfere with cell division. As a product of this damage, a number of chromosomic fragments separate from the main nucleus and come together in a secondary nucleus known as a micronucleus. The research is aimed at seeing how the number of micronuclei vary amongst smoking and non-smoking mothers”.


The research undertaken at the Pediatrícs Laboratory aimed to test the efficacy of the micronuclei technique in detecting instability. “The development of this technology has not been an easy task, and involved working jointly with the CIFA Toxicology Department at the University of Navarre. Specifically, Marta Zalacaín had to carry out a great number of trials in order to test and validate the technique and see how the numbers of micronuclei changed while we increased the benzoapyrene in vitro. In a preliminary manner we found that the micronuclei numbers in vivo increased in samples of those mothers who actively smoked during gestation; nonetheless, these results have to be interpreted with precaution, given that the placentary barrier has to be taken into account and so it can never be known with exactitude how much benzoapyrene is being transmitted to the foetus”.

Apart from benzoapyrene, the research group has studied other genetic markers that tell us about tobacco habits, such as the status of mutation of the TP53 gene and the detoxifying enzymes of phase I and II drugs. “There are enzymes involved in detoxifying the organism which are more or less efficient in various individuals presenting genetic polymorphisms. We are currently looking at the genotype presented in these samples”.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com
http://www.elhuyar.com

More articles from Health and Medicine:

nachricht Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)

nachricht Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Graphene assembled film shows higher thermal conductivity than graphite film

22.06.2018 | Materials Sciences

Fast rising bedrock below West Antarctica reveals an extremely fluid Earth mantle

22.06.2018 | Earth Sciences

Zebrafish's near 360 degree UV-vision knocks stripes off Google Street View

22.06.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>