Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Early results shed light on lung cancer screening advance

22.11.2004


One in three smokers or former smokers screened for lung cancer at a baseline and one year follow-up visit using a recent advance in computed tomography tested positive according to a new study. Of those, 12 percent had lung biopsies, and 7 percent were diagnosed with lung cancer. The findings, along with detailed characterizations of practiced follow-up patterns, appear in the January 1, 2005 issue of CANCER, a peer-reviewed journal of the American Cancer Society.



Low dose spiral computed tomography (LDCT) is currently being evaluated as a more effective alternative to chest radiographs for lung cancer screening through the National Lung Cancer Screening Trial (NLST). LDCT can identify small lesions than x-ray, however, studies have yet to show any improvement in lung cancer mortality using the test.

Paul F. Pinsky, Ph.D. of the National Cancer Institute in Bethesda, Maryland and his colleagues reviewed medical records pertaining to the follow-up of more than 1500 current or former smokers who received LDCT as part of the Lung Screening Study, a multi-center pilot study testing the feasibility of a large-scale nationwide trial. The researchers say 522 were found to have abnormal lung findings. Of those, 12 percent underwent biopsy, 55 percent had a follow-up CT scan but no biopsy, 12 percent were compared to prior x-ray or CT scan, 4 percent had only a clinical exam, and 3 percent received no follow-up. A total of 37 of the 522 subjects (7 percent) were diagnosed with lung cancer within a year of the first positive screen.


The investigators found that only a minority of subjects received a diagnostic work-up according to published algorithms. While biopsy was less likely the smaller the nodule size, surprisingly, the more positive LDCTs the radiologist identified, the lower the rate of the use of biopsy for diagnostic follow-up.

Also, few subjects received follow-up CT in the time commonly recommended for nodule size. For example, only 11 percent of subjects with 4-9mm nodules and 24 percent with 10+mm nodules received a follow-up CT within the recommended 4 months.

In describing the patterns of diagnostic follow-up for people with abnormal findings on LDCT, the authors conclude, the "data may be useful in estimating the potential burden and cost of CT screening and in evaluating whether practitioners are generally following reasonable procedures in their work-up of positive CT screens."

David Greenberg | EurekAlert!
Further information:
http://www.wiley.com
http://www.interscience.wiley.com/cancer-newsroom

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>