Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

All Chronic Sinusitis Is Not Created Equal

18.11.2004


Not all congestion-producing, ear-popping, runny-nosed, headachy chronic rhinosinusitis infections are the same, researchers have found.



Rather, this problem that afflicts some 30 million Americans annually has four severity classifications that could help guide treatment today and help find better treatments in the future, says the lead author on the study published in the November issue of The Laryngoscope. “The way we have been reporting on chronic sinusitis is we lump it all together so we are comparing apples to oranges,” says Dr. Stilianos E. Kountakis, otolaryngologist and vice chair of the Medical College of Georgia Department of Otolaryngology-Head and Neck Surgery. “We treat one patient one way and get this outcome, and we treat a similar patient the same way and get another outcome. Using clinical parameters alone does not really predict well what is going to happen to the patient.”

Researchers decided to factor in some basic science as they took a retrospective look at 55 patients who had surgery for their disease at the University of Virginia at Charlottesville, where Dr. Kountakis was previously on faculty. The studies included clinical parameters, such as preoperative computerized tomography scans and endoscopic exams as well as patient reports of their symptoms based on the Sino-Nasal Outcome Test, or SNOT.


But researchers also looked at the expression of a gene known to contribute to sino-nasal inflammation as well as other indicators of inflammation, including aspirin sensitivity and allergies. Typically, pathology studies completed after surgery indicate whether the patient had polyps, growths that can obstruct sinus passages that are believed to result from the body trying to repair an injured sinus lining. These studies also looked at levels of eosinophils, little exterminator-like cells found in the nose that contain bubbles with toxins that can kill fungi and parasites as they enter. Despite their noble task, when too many of these cells are activated, eosinophils contribute to inflammation and help support polyps.

Not surprisingly, researchers found that patients with both polyps and high levels of eosinophils had the worst disease. The other three categories include patients with polyps without eosinophils, patients without polyps who had eosinophils and patients with neither. “Our analysis showed that disease severity correlated with the presence or absence of polyps (clinical objective parameter) and the presence or absence of sinus tissue eosinophilia (histologic marker),” the researchers write. “All other parameters did not incrementally contribute to this correlation with disease severity.”

Dr. Kountakis already has worked with Dr. Richard B. Hessler, chief of the MCG Section of Anatomic Pathology, to include eosinophil levels on pathology reports for sinusitis patients at MCG Medical Center, a step that could also be taken by other hospitals.

The ability to better categorize this common condition is a good first step in more targeted treatment; for example, patients with higher levels of eosinophils may benefit from more anti-inflammatory agents over longer periods, Dr. Kountakis says.

To simplify categorization, the researchers already are working on a “fingerprint of inflammation” that could be obtained from a simple blood test. “Then, as we design studies to look for still better treatments, we can use this information to compare apples to apples,” says Dr. Kountakis.

Toni Baker | EurekAlert!
Further information:
http://www.mcg.edu

More articles from Health and Medicine:

nachricht Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Color effects from transparent 3D-printed nanostructures

New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference

Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

LaserForum 2018 deals with 3D production of components

17.08.2018 | Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

 
Latest News

Smallest transistor worldwide switches current with a single atom in solid electrolyte

17.08.2018 | Physics and Astronomy

Robots as Tools and Partners in Rehabilitation

17.08.2018 | Information Technology

Climate Impact Research in Hannover: Small Plants against Large Waves

17.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>