Men using the female estrogen hormone replacement therapy (HRT) patches as treatment for advanced prostate cancer suffer fewer side effects than with other treatments, according to a new study reported in the latest issue of the Journal of Urology (December 2004). Scientists at Hammersmith Hospitals NHS Trust and Imperial College London have already shown that HRT patches have considerable potential as prostate cancer therapy. For the first time they have additionally shown that this therapy, unlike other current treatments, prevents bone loss (osteoporosis) and instead causes an increase in bone density. These early studies confirm the considerable promise of estrogen hormone patches in advanced prostate cancer.
Prostate cancer is the most common male cancer in the UK, with about 20,000 cases diagnosed every year. Affecting men generally over the age of 45, prostate cancer grows slowly and may go undetected for many years. In some cases, the cancer can spread to bones and other organs of the body. The causes of prostate cancer are mainly unknown, but it requires the male hormone testosterone, produced in the testicles, to develop and grow. Treatment of advanced disease has resulted in therapies that reduce or remove testosterone from the body, via surgical or medical ‘castration.’
“Depriving the cancer of testosterone is the well accepted method of slowing down the progression of advanced prostate cancer,” comments lead author Mr Paul Abel, consultant urologist at Hammersmith Hospitals NHS Trust and Imperial College London. “The problem is that conventional current therapies which involve testosterone reduction can have serious side effects such as osteoporosis, which has not been fully appreciated until quite recently. This has led to reports of an increasing chance of bone fractures in these patients. Our study shows that oestrogen therapy delivered by skin patches not only controls prostate cancer, but prevents bone loss and in most cases, increases bone mass.”
Simon Wilde | alfa
New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute
Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur
What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...
The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.
Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...
08.08.2018 | Event News
27.07.2018 | Event News
25.07.2018 | Event News
14.08.2018 | Information Technology
14.08.2018 | Life Sciences
14.08.2018 | Life Sciences