Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Alcohol Helps Reduce Damage After Heart Attack

01.09.2004


For years researchers have tried to determine why the French have such a lower rate of cardiovascular disease, given the amount of fat consumed in their diets. Red wine has been identified as one of the suspects in maintaining a healthy heart, but now a University of Missouri-Columbia researcher has found that alcohol, in moderation, from any source not only maintains a healthy heart, but can reduce the damage to affected tissue following a heart attack.



When a heart attack occurs, blood flow is reduced to several areas of the body. When the blood flow is restored, several processes take place in the body that actually cause more harm to the damaged tissue. When the blood supply is reestablished, the blood carries white blood cells to the areas damaged by the reduction in blood delivery. Unfortunately, these blood cells act like miniature hand grenades as they stick to the walls of the arteries and release toxic chemicals into the damaged tissues, causing additional cell death.

“Following a heart attack, physicians try to establish reperfusion, or normalize the blood flow in the body,” said Ron Korthuis, distinguished professor and chair of medical pharmacology and physiology. “The damaged tissues begin releasing a variety of molecules that attract the white blood cells to the damaged areas. When the white blood cells arrive, they attach to the adhesion molecules on the blood vessel walls and then start destroying the damaged tissue. One type of adhesion molecule that is affected by the alcohol ingestion is P-selectin”


P-selectins make the artery walls sticky enough that the white blood cells will attach when they are in the affected areas. Using an animal model, Korthuis found that when alcohol was introduced to the system at a rate of one drink every 48 hours, the alcohol would trigger a chemical reaction in the body that would make the artery walls slick and stop the white blood cells from attaching to the damaged tissue. In subjects that were treated with the alcohol, the tissue affected by the low blood flow was much healthier and stronger than the untreated tissue. However, Korthuis warns that this is not a license to drink.

“Every time you take a drink of alcohol, you’re killing brain cells,” Korthuis said. “We’re trying to identify these chemical reactions so that we can develop a drug that would start this chain reaction, but not have the side effects of alcohol. We’ve also found other natural compounds have similar effects such as capsaicin, a compound in Tabasco sauce that creates that hot sensation.”

Korthuis’ research will be published this fall in Microcirculation. He also has been published in the American Journal of Physiology and Free Radicals Biology and Medicine on similar research studies.

| newswise
Further information:
http://www.missouri.edu

More articles from Health and Medicine:

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

nachricht Distrust of power influences choice of medical procedures
01.08.2018 | Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

Im Focus: World record: Fastest 3-D tomographic images at BESSY II

The quality of materials often depends on the manufacturing process. In casting and welding, for example, the rate at which melts solidify and the resulting microstructure of the alloy is important. With metallic foams as well, it depends on exactly how the foaming process takes place. To understand these processes fully requires fast sensing capability. The fastest 3D tomographic images to date have now been achieved at the BESSY II X-ray source operated by the Helmholtz-Zentrum Berlin.

Dr. Francisco Garcia-Moreno and his team have designed a turntable that rotates ultra-stably about its axis at a constant rotational speed. This really depends...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

'Building up' stretchable electronics to be as multipurpose as your smartphone

14.08.2018 | Information Technology

During HIV infection, antibody can block B cells from fighting pathogens

14.08.2018 | Life Sciences

First study on physical properties of giant cancer cells may inform new treatments

14.08.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>