Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Pioneering the basics for new kind of cancer vaccine

02.08.2004


Mayo Clinic and British researchers have developed a new approach to cancer vaccines that purposely kills healthy skin cells to target the immune system against tumors. The new approach has eradicated skin cancer tumors in mice. The approach and results challenge conventional thinking on the creation of cancer vaccines. Their report on the "heat shock" vaccine therapy appears in the August issue of Nature Biotechnology, Results are promising because multiple rounds of treatment eradicated skin cancer in all the mice in the study. If this work can be extended to humans, it could have enormous benefits. Skin cancer is currently the most common form of cancer in the United States, with an estimated one million new cases diagnosed annually.


Significance of the Mayo Clinic Research

Normally, the destruction of healthy cells is undesirable. For example, in toxic conventional chemotherapies for cancer, the goal is to kill cancer cells and spare healthy cells. This new approach is significant for two reasons:

1) It turns the death of healthy cells into a therapeutic advantage by inflicting a stress known as "inflammatory cell death" on skin cells to which researchers attached a protein involved in heat shock. Researchers were able to trigger a healing immune response aimed at the skin cancer tumors. The response was so strong it eradicated the tumors.



2) Researchers avoided triggering autoimmune attacks, which are a common disabling side effect of most cancer vaccine attempts. In autoimmune attacks the body attacks and injures itself -- instead of the cancer. This new approach appears to breach a major obstacle to advancing cancer vaccine research from the laboratory into human trials.

"We’re very encouraged by these results because our main interest is in generating cancer vaccines that will stimulate the immune system to recognize tumors and eradicate them. We hope our novel approach will be a more specific, and therefore gentler therapy for patients,’’ says Mayo immunologist and lead researcher Richard Vile, Ph.D.

Background

To test the idea that killing normal cells might trigger a specific immune system response, the team chose normal skins cells called melanocytes that are involved in the highly lethal cancer malignant melanoma. The researchers created a molecular scout to home in on and kill some of the melanocytes in mice. To the molecular scout they attached an unusual protein, called heat shock protein 70, or hsp70. It normally is not present in healthy cells, but when cells die under certain conditions, they release hsp70. "It’s a danger-signal system that the body is in trouble," says Dr. Vile. "We hoped to trigger an anti-tumor response."

The unanticipated result was a two-step reaction with promising traits that may one day help skin cancer patients. In the first step, the heat shock protein recruited T cells -- the main warriors of the immune system -- that attacked melanocytes. The T cells killed all tumors in the mice.

Researchers also questioned whether a raging T-cell attack might prompt autoimmune disease. The immune system apparently anticipated that. In response to the vaccine, it sent out regulatory T cells to calm down the first group of fighting T cells.

Says Dr. Vile: "The nice twist is that originally we thought we would generate a very potent autoimmune disease before we killed the tumor. But we found just the opposite. What happens is that you get a burst of T cells that kill the melanoma, and then they are suppressed by regulatory T cells in the mouse before they cause autoimmune disease."

For humans, this is good news. "This is very hopeful because we think in the clinic there are good chances we can control anti-tumor effects before we get to the autoimmune problems," says Dr. Vile.

The Next Step

The researchers will pursue two basic paths. One will extend the current work on a heat shock vaccine to other tissue and tumor types to determine its effectiveness against breast, lung or prostate cancers. The other is to test this immunotherapy in clinical trials with humans.

Bob Nellis | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Health and Medicine:

nachricht Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine

nachricht UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers develop method to transfer entire 2D circuits to any smooth surface

What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.

Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...

Im Focus: Three components on one chip

Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.

Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...

Im Focus: Substitute for rare earth metal oxides

New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals

Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.

Im Focus: A bit of a stretch... material that thickens as it's pulled

Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.

Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...

Im Focus: The force of the vacuum

Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.

The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

Expert Panel on the Future of HPC in Engineering

03.12.2018 | Event News

 
Latest News

Small but ver­sat­ile; key play­ers in the mar­ine ni­tro­gen cycle can util­ize cy­anate and urea

10.12.2018 | Life Sciences

New method gives microscope a boost in resolution

10.12.2018 | Physics and Astronomy

Carnegie Mellon researchers probe hydrogen bonds using new technique

10.12.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>