Finding cancer in a tiny drop of body fluid containing relatively few cells now may be possible with a new method of analyzing multiple genes in small samples of DNA, the cellular building blocks of our genetic code. The molecular test may be especially helpful in detecting cancer cells in breast fluid.
Preliminary tests of the new method, which can detect cancer in a sample with as few as 50 cells, were conducted on a small number of breast tissue samples and are reported in the July 1 issue of Cancer Research. "Our goal is to add a molecular solution to problems in cancer diagnosis where the sample is not adequate or microscopic evaluation of cells is unclear," says Sara Sukumar, Ph.D., the Barbara B. Rubenstein Professor of Oncology at the Johns Hopkins Kimmel Cancer Center. "If additional studies prove the feasibility of this test, it will provide molecular clues to cellular pathology and mammography findings that may help to decide whether cancer is present."
The test, called quantitative multiplex methylation-specific PCR or QM-MSP, works by looking for unusually high levels of molecules embedded by a process called methylation within critical regions of DNA. In this process, small methyl groups regulate DNAs message-manufacturing process by attaching to the "on" switch of genes. Abnormal levels of methylation improperly turn the gene switch off, which ultimately leads to the loss of critical proteins found in normal cells. This adds to the cascade of genetic events leading to cancer.
Using fragment-based approaches to discover new antibiotics
21.06.2018 | SLAS (Society for Laboratory Automation and Screening)
Scientists learn more about how gene linked to autism affects brain
19.06.2018 | Cincinnati Children's Hospital Medical Center
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...
Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
22.06.2018 | Materials Sciences
22.06.2018 | Earth Sciences
22.06.2018 | Life Sciences