Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Radiation Oncologists Expanding Scope of Life-saving Accuray Technology

23.07.2004


Thirty-one-year-old Karen Romero, blinded by a malignant brain tumor, had endured two years of chemotherapy before her cancer was finally eradicated at UT Southwestern Medical Center at Dallas with a new means of delivering radiation therapy.


Dr. Hak Choy (left), chairman of radiation oncology, and Dr. Lawrence Chinsoo Cho, associate professor of radiation oncology, are overseeing a new clinical trial for liver cancer using the Accuray, which pinpoints high-beam radiation therapy on cancer cells with unprecedented accuracy.



She believes – as do her doctors – that the treatment she received, which pinpoints high-beam radiation therapy on cancer cells with unprecedented accuracy, saved her life. After only two treatments, her ocular germinoma tumor appears to be gone.

The device used to deliver the radiation, called the Accuray CyberKnife, is in use at only a handful of medical centers in the United States. UT Southwestern doctors are hoping to expand its scope. They are seeking patients whose cancer has spread, or metastasized, to the liver to participate in a new series of clinical trials.


“I think this kind of treatment was very beneficial for me because of its effectiveness and a lack of side effects,” said Ms. Romero of Garland. “For example, I did not have any hair loss as I did with conventional chemotherapy, and there was less recuperation time and fatigue.”

Dr. Lawrence Chinsoo Cho, associate professor of radiation oncology at UT Southwestern, said the Accuray targets within a millimeter of cancerous cells while leaving surrounding healthy tissue unharmed. Instead of standard chemotherapy or conventional stereotactic radiosurgery systems that require rigid skeletal immobilization and have limited maneuverability, the Accuray employs a linear accelerator on a robotic arm to locate the position of the tumor and to focus beams of radiation on it. It compensates for body movement by keeping the beams focused precisely on the tumor.

“We have plenty of experience with the device, having used it for tumors of the brain, head and neck, base of the skull, cervical spine, pancreas and prostate,” said Dr. Hak Choy, chairman of radiation oncology. “We’re continually finding new uses for the Accuray because of its various unique capabilities.”

The device is cleared by the Food and Drug Administration for radiosurgery for lesions anywhere in the body when radiation treatment is needed.

“We’re tackling fights that were not possible to tackle before the advent of this technology,” said Dr. Cho, principal investigator for the new clinical trial. “We are going after tumors we have not treated routinely, and instead of going to the operating room and the recovery room, this can be done as an outpatient procedure.”

Approximately 40 patients are needed for the initial phase of the trial, which is expected to last for a year to 18 months and is designed to find the right treatment dose and assess toxicity. Participant responses to treatment will be determined by positron emission tomography scans prior to and about two months after the last treatment. There will be three Accuray treatments over a seven- to 10-day period, with each procedure taking a couple of hours on an outpatient basis.

The second phase of the clinical trial will enroll another 30 metastasized liver cancer patients to evaluate the overall response and efficacy of the Accuray, said Dr. Cho.

Pre- and postoperative procedures will be conducted at the Moncrief Radiation Oncology Center and the Accuray treatments themselves will take place at Zale Lipshy University Hospital – both UT Southwestern facilities. Patients will have an initial consultation with Dr. Cho and the other doctors in the clinical trial team and undergo a computed tomography scan to construct a 3-D image of the tumor and develop a customized treatment plan.

Tiny seeds will be permanently placed in the abdomen region to define the areas of treatment. The Accuray’s image-guidance system uses the seeds to precisely localize and track the spatial position of the liver at the start of and throughout each radiation treatment.

As for Ms. Romero, mother of 5-year-old Isaac, “I wouldn’t be alive today if it weren’t for the Accuray – and the UT Southwestern doctors. They quite simply saved my life.”

| newswise
Further information:
http://www.utsouthwestern.edu

More articles from Health and Medicine:

nachricht Foods of the future
15.08.2018 | Georg-August-Universität Göttingen

nachricht New antibody analysis accelerates rational vaccine design
09.08.2018 | Scripps Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Unraveling the nature of 'whistlers' from space in the lab

A new study sheds light on how ultralow frequency radio waves and plasmas interact

Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...

Im Focus: New interactive machine learning tool makes car designs more aerodynamic

Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.

When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...

Im Focus: Robots as 'pump attendants': TU Graz develops robot-controlled rapid charging system for e-vehicles

Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.

Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....

Im Focus: The “TRiC” to folding actin

Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.

Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...

Im Focus: Lining up surprising behaviors of superconductor with one of the world's strongest magnets

Scientists have discovered that the electrical resistance of a copper-oxide compound depends on the magnetic field in a very unusual way -- a finding that could help direct the search for materials that can perfectly conduct electricity at room temperatur

What happens when really powerful magnets--capable of producing magnetic fields nearly two million times stronger than Earth's--are applied to materials that...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Within reach of the Universe

08.08.2018 | Event News

A journey through the history of microscopy – new exhibition opens at the MDC

27.07.2018 | Event News

2018 Work Research Conference

25.07.2018 | Event News

 
Latest News

Unraveling the nature of 'whistlers' from space in the lab

15.08.2018 | Physics and Astronomy

Diving robots find Antarctic winter seas exhale surprising amounts of carbon dioxide

15.08.2018 | Earth Sciences

Early opaque universe linked to galaxy scarcity

15.08.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>