Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Drug Can Induce Tanning When Used with Sunlight or Simulated UV-B Light

21.07.2004


Melanotan-1, a synthetic agent similar to the body’s hormone that regulates skin pigmentation, can be combined with UV-B light or sunlight, and appears to act synergistically in the tanning response to light, according to an article in the July issue of The Archives of Dermatology, one of the JAMA/Archives journals.



Melanotan-1 (MT-1) is a synthetic super-potent derivative of its natural counterpart, alpha-melanocyte-stimulating hormone, one of a family of hormones that induce pigmentation in the body. According to information in the article, the authors previously demonstrated that MT-1 can induce tanning in human volunteers who are known to tan easily in response to sunlight. All previously reported clinical trials with MT-1 were performed with volunteers who were instructed to avoid sunlight and use sunscreens with a sun-protective factor rating of 30 on all skin sites exposed to the sun. The effect of MT-1 when combined with either sunlight or simulated UV-B radiation had not been tested.

Robert T. Dorr, Ph.D., of the University of Arizona, Tucson, and colleagues performed three phase one clinical trials to demonstrate safety for MT-1 therapy combined with UV-B light or sunlight. In the first study, four subjects were randomized to 0.08 milligrams per kilogram of MT-1 per day administered by injection, and four others received injections of isotonic sodium chloride solution (solution containing the same concentration of salt as normal body fluids) for ten days. It was followed by neck irradiation with UV-B light.


In the second study, 12 subjects received MT-1. The dosage was increased to 0.16 milligrams per kilogram per day for ten days, with UV-B radiation given to a buttock site for five days during or after MT-1 administration. The final study randomized eight subjects to three to five days of sunlight to half of the back, or to sunlight plus 0.16 milligrams per kilogram of MT-1, for five days per week for four weeks.

“The results show that the synthetic super-potent melanotropin, MT-1, can be safely combined with small amounts of UV-B from a solar simulator or with brief exposures to full sunlight,” the authors report. “We have further shown that MT-1 can be administered for 20 days over four weeks at a daily dose of 0.16 milligrams per kilogram without producing cumulative, more intense or new adverse effects.”

Tanning was achieved in three of four subjects receiving MT-1 in the first study. These subjects also had 47 percent fewer sunburn cells at the irradiated site. More skin sites darkened with the higher dose of MT-1 in the second study. In the third study, there was significantly enhanced tanning in the MT-1 group, and it was maintained at least three weeks longer than the tanning in those who were randomized to sunlight only. The controls required 50 percent more sun exposure time for equivalent tanning.

“There were no pathologic findings at any UV-B or sun-exposed sites in any subject,” the authors write. “Toxic effects due to MT-1 were minor, consisting of nausea and transient facial flushing.”

“Perhaps the most important observation in the three clinical studies of MT-1 is the observation of marked tanning synergy with the combination of UV-B light (protocol 2) or sunlight (protocol 3),” they suggest. “The degree of skin darkening measured at both light exposed sites was significantly greater than that achieved with UV light, sunlight, or drug alone.”

| newswise
Further information:
http://www.ama-assn.org
http://www.archdermatol.com

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New gene potentially involved in metastasis identified

Gene named after Roman goddess Minerva as immune cells get stuck in the fruit fly’s head

Cancers that display a specific combination of sugars, called T-antigen, are more likely to spread through the body and kill a patient. However, what regulates...

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Searching for disappeared anti-matter: A successful start to measurements with Belle II

26.03.2019 | Physics and Astronomy

Extremely accurate measurements of atom states for quantum computing

26.03.2019 | Physics and Astronomy

Listening to the quantum vacuum

26.03.2019 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>