Like a parasite exploiting its host, some tumors protect themselves by recruiting non-tumor cells that normally help keep the immune system in check, say researchers at the Medical College of Georgia.
When the researchers looked into the lymph nodes where tumors drain – typically the first place tumors spread – they found a subset of normal host immune cells were expressing IDO, an immunosuppressive enzyme also expressed by the fetus to help avoid rejection by the mothers immune system. They also found that when they gave a drug to block IDO expression, the immune system rallied.
"Our hypothesis in this situation was that the bad guys in this case were actually cells from the host, perfectly normal cells that had, in a sense, been requested by the tumor," says Dr. David Munn, pediatric hematologist-oncologist and lead author on the study published in the July 15 issue of Journal of Clinical Investigation.
Toni Baker | EurekAlert!
New method uses just a drop of blood to monitor lung cancer treatment
19.10.2018 | Osaka University
Photoactive bacteria bait may help in fight against MRSA infections
12.10.2018 | Purdue University
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
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