Novel and Effective Treatment for Soft Tissue Sarcoma in Children

Rhabdomyosarcoma is a highly malignant aggressive form of soft tissue cancer in children, the causes of which are currently unknown. Although the fibrous growths can be found all over the body they commonly develop around the head, neck, bladder and testes in young boys. The most common age for onset is between 1-5 years of age. The treatments used are usually chemotherapy using a combination of drugs, radiotherapy and surgery and although quite effective (66% success rate at present), the side affects commonly experienced by the young patients are very unpleasant and the whole process can prove to be very traumatic not only for the patient but for the families too. So there is a need for a better way of treating the disease.

At present the cocktail of drugs administered through the chemotherapy route are not selective to the cancer cells and so they also attack healthy cells. In order for the treatment to be effective without causing unnecessary tissue damage, researchers have been looking for ways to specifically target the cancer cells in order to deliver the therapeutic agent that will kill the tumour.

An unexpected link between rhabdomyosarcoma and a particular form of a disease known as myasthenia gravis was recently discovered by University scientists. Research was being carried out at the University of Oxford amongst women suffering from spontaneous miscarriages caused by an autoimmune response to their own foetus. It was then discovered that the mothers were producing antibodies against a molecule on the surface of the foetal cells which was the same as that present on the surface of the rhabdomyosarcoma cells. Scientists at the University of Würzburg then made molecules that were smaller fragments of the antibody but which would still have the same attraction for the rhabdomyosarcoma cells as for the original antibody. A gene that encodes the fragments was then transferred into a bacteria containing the DNA for a toxin. An immunotoxin was then produced containing the antibody fragment and the toxin together which is able to target the sarcoma cells using the antibody fragment and kill them with the toxin.

The immunotoxin has already been tested in a good model system and the positive results achieved have been able to show the therapeutic potential of the technique. The antibody fragment is also able to carry other toxins or even radioactive elements such as Yttrium for delivery to the site of a tumour.

Dr Richard Middleton, the project manager from Isis Innovation Ltd, the technology transfer company for the University of Oxford stated, “This is excellent science leading to an application which may be of real benefit to people in an area of currently unmet need”.

Media Contact

newswise

More Information:

http://www.isis-innovation.com

All latest news from the category: Health and Medicine

This subject area encompasses research and studies in the field of human medicine.

Among the wide-ranging list of topics covered here are anesthesiology, anatomy, surgery, human genetics, hygiene and environmental medicine, internal medicine, neurology, pharmacology, physiology, urology and dental medicine.

Back to home

Comments (0)

Write a comment

Newest articles

Lighting up the future

New multidisciplinary research from the University of St Andrews could lead to more efficient televisions, computer screens and lighting. Researchers at the Organic Semiconductor Centre in the School of Physics and…

Researchers crack sugarcane’s complex genetic code

Sweet success: Scientists created a highly accurate reference genome for one of the most important modern crops and found a rare example of how genes confer disease resistance in plants….

Evolution of the most powerful ocean current on Earth

The Antarctic Circumpolar Current plays an important part in global overturning circulation, the exchange of heat and CO2 between the ocean and atmosphere, and the stability of Antarctica’s ice sheets….

Partners & Sponsors