Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Link established between presence of a key protein and the aggressiveness of prostate cancer

15.07.2004


Prostate cancer is much more likely to be aggressive if a key protein called Stat5 is found activated and in abundance in the cancer cells, report researchers from Georgetown University’s Lombardi Comprehensive Cancer Center. By inhibiting this protein, called Stat5, doctors are exploring how to develop a new treatment strategy for advanced prostate cancer.



The new findings, reported in the July 15th issue of the journal Cancer Research, show that active Stat5 protein is particularly plentiful in high histological grade human prostate cancer. High histological grade prostate cancers have often already metastasized by the time of diagnosis and are typically more aggressive in growth.

"Currently, there are only few treatment options available for advanced prostate cancer," said Marja Nevalainen, MD, PhD, assistant professor of oncology at Georgetown University Lombardi Comprehensive Cancer Center. "If we can find a way to stop Stat5 from turning on in prostate cancer cells, we may be able to devise a new strategy for treating this disease."


Previous studies by Nevalainen show that when the "telephone line" that sends signals to turn Stat5 on is blocked, human prostate cancer cells die. When the line remains open for communication, allowing Stat5 to send cellular signals, prostate cancer cells stay alive and thrive. Nevalainen’s work is focused on finding ways to short-circuit the signals that turn on Stat5, thus killing prostate cells before they flourish.

In this study, human prostate cancer specimens, which are routinely collected during prostate cancer surgeries for analysis of the histological grade of each prostate cancer, were analyzed for activation of Stat5. Activation of Stat5 was then correlated statistically with the histological grade of each specimen.

Nevalainen sees dual possibilities for where the future of Stat 5 research may one day lead: development of potential treatments and identifying whether Stat5 could serve as an effective sign for diagnosing cancer. "We are in the process of determining whether activation of Stat5 in prostate cancer would serve as an effective prognostic biomarker. Development of additional diagnostics, beyond the PSA test, may help physicians on the frontlines of cancer detection."

Lindsey Spindle | EurekAlert!
Further information:
http://www.gumc.georgetown.edu

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Solving the efficiency of Gram-negative bacteria

22.03.2019 | Life Sciences

Bacteria bide their time when antibiotics attack

22.03.2019 | Life Sciences

Open source software helps researchers extract key insights from huge sensor datasets

22.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>