Protein changes shape to let salts and other solutes in and out of the cell through a process called ’gating’ in order to keep tension on the membrane steady
New findings about a protein that keeps cells alive by opening and closing pores within a cell’s membrane may open the door to the development of new antibiotics. Researchers at UT Southwestern Medical Center at Dallas are studying a protein, called MscL, found in the membrane of the single-cell bacterium Escherichia coli. The protein is essentially an emergency-response valve that changes shape to let salts and other solutes in and out of the cell through a process called "gating" in order to keep tension on the membrane steady. This gating process allows some of the cell’s innards to spill out or liquid from the surrounding environment to rush in.
If this protein – a type of which is found in nearly all microbes – doesn’t function properly, the cell may die. The researchers have refined previous descriptions of MscL, which may have implications for potential drug therapies designed to kill microorganisms. They also developed a novel way to manipulate the protein’s gating, thus killing the bacteria. The findings will appear in an upcoming issue of the Proceedings of the National Academy of Sciences and are available online.
Amanda Siegfried | EurekAlert!
Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering
New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center
Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.
Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...
The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.
Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...
What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...
A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.
The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...
A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.
Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...
12.12.2018 | Event News
10.12.2018 | Event News
06.12.2018 | Event News
18.12.2018 | Materials Sciences
18.12.2018 | Physics and Astronomy
18.12.2018 | Physics and Astronomy