Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein marker predicts possible heart damage after chemotherapy

18.05.2004


High levels of troponin I (TNI) protein in the blood helps identify possible heart damage after cancer treatment, according to a report in today’s rapid access issue of Circulation: Journal of the American Heart Association.



The report also suggests that tracking TNI levels can help doctors form a heart disease prevention plan for some chemotherapy patients. "Damage to the heart is one of the most worrisome long-term side effects of high-dose chemotherapy," said lead author Daniela Cardinale, M.D., deputy director of the cardiology unit at the European Institute of Oncology in Milan, Italy. "Therefore, it is important to identify biochemical markers that might indicate which patients are at greatest risk and how severe their heart disease might be."

TNI is a protein present exclusively in heart cells. The TNI blood concentration is a well-established marker of heart muscle injury that’s widely used to diagnose and treat heart attacks and other acute coronary syndromes.


"Our study is the first to clearly show, in an adult population, that the risk of cardiac events in cancer patients can be predicted by evaluating the TNI release pattern after chemotherapy," Cardinale said.

In cancer patients who have had chemotherapy, physicians usually use extensive testing and expensive monitoring equipment to identify which patients may have cardiac toxicity, Cardinale said. These methods "have low sensitivity, poor predictive value and, in some cases, technical limitations. Moreover, these methods identify cardiac damage only when it has already occurred and, in most cases, is not reversible," she said. "Evaluating TNI value after chemotherapy is an easy, non-invasive, low-cost method that allows us to categorize the risk of cardiac events in cancer patients in the three years following chemotherapy."

Researchers took blood samples of 703 cancer patients to measure TNI soon after high-dose chemotherapy and one month later. TNI values higher than 0.08 nanograms per milliliter (ng/mL) were considered TNI "positive," while lower values were TNI "negative." They found that 145 patients (21 percent) were TNI positive right after chemotherapy, and 63 patients (9 percent) were positive immediately after chemotherapy and one month later.

The researchers found no significant reduction in heart function at the three-year follow-up in patients who were TNI negative. These patients had only a 1 percent incidence of cardiac events, such as heart attacks.

In contrast, the cardiac event incidence was 37 percent among the patients who were TNI positive immediately after chemotherapy and 84 percent among those who remained positive a month later.

Cardinale said the study has several important implications for cancer treatment:
  • TNI categorizes heart disease risk early, long before impairment in heart function and symptoms develop, and when many preventive treatments would probably help prevent long-term health effects.

  • TNI could assess and monitor the safety and effectiveness of different treatments.

  • Heart-protective therapies that might limit or prevent the TNI rise after chemotherapy, and heart treatments that interfere with TNI persistence could improve the future heart health of these patients.

"The results of this study provide a rational need for doctors to use this marker to guide them in their cardiac evaluations and treatments of high-dose chemotherapy patients," Cardinale said.

Co-authors are: Maria T. Sandri, M.D.; Alessandro Colombo, M.D.; Nicola Colombo, M.D.; Marina Boeri, M.S.; Giuseppina Lamantia, M.D.; Maurizio Civelli, M.D.; Fedro Peccatori, M.D.; Giovanni Martinelli, M.D.; Cesare Fiorentini, M.D.; and Carlo M. Cipolla, M.D.

Carole Bullock | EurekAlert!
Further information:
http://www.americanheart.org/

More articles from Health and Medicine:

nachricht UIC researchers find unique organ-specific signature profiles for blood vessel cells
18.02.2020 | University of Illinois at Chicago

nachricht Remdesivir prevents MERS coronavirus disease in monkeys
14.02.2020 | NIH/National Institute of Allergy and Infectious Diseases

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A step towards controlling spin-dependent petahertz electronics by material defects

The operational speed of semiconductors in various electronic and optoelectronic devices is limited to several gigahertz (a billion oscillations per second). This constrains the upper limit of the operational speed of computing. Now researchers from the Max Planck Institute for the Structure and Dynamics of Matter in Hamburg, Germany, and the Indian Institute of Technology in Bombay have explained how these processes can be sped up through the use of light waves and defected solid materials.

Light waves perform several hundred trillion oscillations per second. Hence, it is natural to envision employing light oscillations to drive the electronic...

Im Focus: Freiburg researcher investigate the origins of surface texture

Most natural and artificial surfaces are rough: metals and even glasses that appear smooth to the naked eye can look like jagged mountain ranges under the microscope. There is currently no uniform theory about the origin of this roughness despite it being observed on all scales, from the atomic to the tectonic. Scientists suspect that the rough surface is formed by irreversible plastic deformation that occurs in many processes of mechanical machining of components such as milling.

Prof. Dr. Lars Pastewka from the Simulation group at the Department of Microsystems Engineering at the University of Freiburg and his team have simulated such...

Im Focus: Skyrmions like it hot: Spin structures are controllable even at high temperatures

Investigation of the temperature dependence of the skyrmion Hall effect reveals further insights into possible new data storage devices

The joint research project of Johannes Gutenberg University Mainz (JGU) and the Massachusetts Institute of Technology (MIT) that had previously demonstrated...

Im Focus: Making the internet more energy efficient through systemic optimization

Researchers at Chalmers University of Technology, Sweden, recently completed a 5-year research project looking at how to make fibre optic communications systems more energy efficient. Among their proposals are smart, error-correcting data chip circuits, which they refined to be 10 times less energy consumptive. The project has yielded several scientific articles, in publications including Nature Communications.

Streaming films and music, scrolling through social media, and using cloud-based storage services are everyday activities now.

Im Focus: New synthesis methods enhance 3D chemical space for drug discovery

After helping develop a new approach for organic synthesis -- carbon-hydrogen functionalization -- scientists at Emory University are now showing how this approach may apply to drug discovery. Nature Catalysis published their most recent work -- a streamlined process for making a three-dimensional scaffold of keen interest to the pharmaceutical industry.

"Our tools open up whole new chemical space for potential drug targets," says Huw Davies, Emory professor of organic chemistry and senior author of the paper.

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

70th Lindau Nobel Laureate Meeting: Around 70 Laureates set to meet with young scientists from approx. 100 countries

12.02.2020 | Event News

11th Advanced Battery Power Conference, March 24-25, 2020 in Münster/Germany

16.01.2020 | Event News

Laser Colloquium Hydrogen LKH2: fast and reliable fuel cell manufacturing

15.01.2020 | Event News

 
Latest News

"Make two out of one" - Division of Artificial Cells

19.02.2020 | Life Sciences

High-Performance Computing Center of the University of Stuttgart Receives new Supercomuter "Hawk"

19.02.2020 | Information Technology

A step towards controlling spin-dependent petahertz electronics by material defects

19.02.2020 | Power and Electrical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>