Individuals who have a variation of the COX-2 gene have an associated lower risk for a heart attack or stroke, according to a study in the May 12 issue of The Journal of the American Medical Association (JAMA).
Although myocardial infarction (MI, or heart attack) and atherothrombotic ischemic stroke are thought to be caused by rupture of vulnerable atherosclerotic plaques, they are recognized to be complex disorders that likely result from multifaceted interactions between an individual’s genetic makeup and environmental factors, according to background information in the article. The relation between COX-2 variations and the risk of MI and stroke has not been clear.
Francesco Cipollone, M.D., of the G. d’Annunzio University of Chieti and G. d’Annunzio University Foundation, Chieti, Italy and colleagues conducted a study to determine if there was a relationship between a variation in the COX-2 gene (termed the "-765G-C polymorphism") and clinically evident plaque rupture. The study was conducted between March 2002 and October 2003 among 864 patients with first MI or atherothrombotic ischemic stroke and 864 hospitalized controls. The groups were matched for age, sex, body mass index, smoking, hypertension, hypercholesterolemia, and diabetes.
Andrea Mezzetti | EurekAlert!
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