Use of tamoxifen by high risk women is low due to both failure of doctors to offer it and patients refusal to accept it, according to the results of a new study led by researchers at Northwestern Memorial Hospital. While tamoxifen chemoprevention has been shown to reduce the occurrence of breast cancer by nearly 50 percent in women with elevated risk, this study shows that the drugs risks and benefits arent always appropriately evaluated when determining who should take it.
The study, which will be published March 22, 2004 in the online edition of CANCER, is the largest to date to review use of the drug in risk-eligible women.
"The study shows that doctors tend to offer tamoxifen to women who will reap the greatest benefit from the drug due to risk caused by certain types of benign breast disease and to those at lower risk of severe side effects. That makes sense," explains Monica Morrow, M.D., the studys lead author and director of breast surgery at Northwestern Memorial Hospital. "What doesnt make sense is that women significantly less likely to have side effects, such as premenopausal women and those without a uterus, did not accept tamoxifen more frequently than other groups." Dr. Morrow is also a professor of surgery at Northwestern Universitys Feinberg School of Medicine.
Patty Keiler | EurekAlert!
Photoactive bacteria bait may help in fight against MRSA infections
12.10.2018 | Purdue University
15 emerging technologies that could reduce global catastrophic biological risks
10.10.2018 | Johns Hopkins Center for Health Security
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
New measurement method allows researchers to precisely follow the movement of individual molecules over long periods of time
The function of proteins – the molecular tools of the cell – is governed by the interplay of their structure and dynamics. Advances in electron microscopy have...
16.10.2018 | Event News
02.10.2018 | Event News
01.10.2018 | Event News
16.10.2018 | Life Sciences
16.10.2018 | Physics and Astronomy
16.10.2018 | Event News