Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Kidney transplant patients who develop diabetes show poor short-term outcomes

24.02.2004


Patients who develop diabetes shortly after kidney transplantation have poorer short-term outcomes than those who had the disease before transplant, according to a Penn State Milton S. Hershey Medical Center study.



"Because patients with diabetes often pose many medical challenges due to the complications of the disease, it was surprising to see that these patients who’d been dealing with diabetes for years, ended up better off than the patients who only developed diabetes after their transplants," said Robert Gabbay, M.D., Ph.D., associate professor of medicine, co-director, Penn State Diabetes Center, and principal investigator of the study, which appeared in the December 2003 issue of Transplantation Proceedings. "Overall, patients who developed post-transplant diabetes were most vulnerable to kidney rejection, infection and additional hospitalization."

The study included 181 kidney transplant patients at Penn State Milton S. Hershey Medical Center from January 1999 to December 2000. The patients were divided into three groups: those who had diabetes prior to kidney transplant, those who developed diabetes mellitus within 24 weeks after transplant; and those who did not have diabetes mellitus before or after transplant. Data was collected before and after the patients’ transplants.


Results showed that about 22 percent of previously non-diabetic patients developed post-transplant diabetes within six months of kidney transplant. About 57 percent of those patients developed an infection compared to 35 percent of patients who had diabetes prior to transplant and 21 percent of patients who did not have or develop diabetes. Patients who developed post-transplant diabetes also were more likely to have recurrent infections than the other two patient groups.

"We would expect that patients who were recently diagnosed with diabetes wouldn’t yet be suffering from complications, yet our study showed that they do have poorer kidney transplant outcomes," Gabbay said.

Although few in number, previous long-term studies showed that the standard post-transplant drug therapies taken to help patients avoid organ rejection can actually cause patients to develop diabetes. Limited data form other studies also has suggested that post-transplant diabetes is associated with higher rates of long-term sickness and death primarily due to an increase in infections or heart and vascular problems.

"This study focused on the first six months after transplant because short term rehospitalization is a great concern for transplant patients," Gabbay said. "If bad outcomes start early, then earlier interventions may be helpful for the long-term health of the patients." Gabbay said the health information presented in the long-term outcomes studies may include influences from other medical complications of diabetes. Focusing on the short term may remove any influences from the long-term complications of diabetes and allow the researchers to focus on the glucose values. Tight control of glucose, or blood sugar, with the use of insulin is important for all patients with diabetes to remain healthy.

"We believe that the poor outcomes in those who develop diabetes after kidney transplant may have something to do with glucose levels and we plan to study that next," Gabbay said. "We hope that medical interventions early could lead to better outcomes for these patients in the long run."

Co-authors on the study were: T.F.M. Saleem, M.D., fellow; K.E. Cunningham, medical student, Penn State College of Medicine, C.S. Hollenbeak, Ph.D., assistant professor of surgery and health evaluation sciences; and E. J. Alfrey, M.D., professor of surgery, Penn State College of Medicine, Penn State Hershey Medical Center.


Penn State Diabetes Center is a partnership of scientists and medical specialists whose continued goal is to increase the scientific and medical knowledge needed to eradicate diabetes, and help those with diabetes to live better, healthier lives. Penn State Diabetes Center is piloting a new integrated system – the first of its kind in Pennsylvania and only the second in the nation – to help primary care physicians to make sure that patients with diabetes are getting all of the recommended screenings and tests.

Valerie Gliem | EurekAlert!
Further information:
http://www.psu.edu/

More articles from Health and Medicine:

nachricht Collagen nanofibrils in mammalian tissues get stronger with exercise
14.12.2018 | University of Illinois College of Engineering

nachricht New discoveries predict ability to forecast dementia from single molecule
12.12.2018 | UT Southwestern Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Data storage using individual molecules

Researchers from the University of Basel have reported a new method that allows the physical state of just a few atoms or molecules within a network to be controlled. It is based on the spontaneous self-organization of molecules into extensive networks with pores about one nanometer in size. In the journal ‘small’, the physicists reported on their investigations, which could be of particular importance for the development of new storage devices.

Around the world, researchers are attempting to shrink data storage devices to achieve as large a storage capacity in as small a space as possible. In almost...

Im Focus: Data use draining your battery? Tiny device to speed up memory while also saving power

The more objects we make "smart," from watches to entire buildings, the greater the need for these devices to store and retrieve massive amounts of data quickly without consuming too much power.

Millions of new memory cells could be part of a computer chip and provide that speed and energy savings, thanks to the discovery of a previously unobserved...

Im Focus: An energy-efficient way to stay warm: Sew high-tech heating patches to your clothes

Personal patches could reduce energy waste in buildings, Rutgers-led study says

What if, instead of turning up the thermostat, you could warm up with high-tech, flexible patches sewn into your clothes - while significantly reducing your...

Im Focus: Lethal combination: Drug cocktail turns off the juice to cancer cells

A widely used diabetes medication combined with an antihypertensive drug specifically inhibits tumor growth – this was discovered by researchers from the University of Basel’s Biozentrum two years ago. In a follow-up study, recently published in “Cell Reports”, the scientists report that this drug cocktail induces cancer cell death by switching off their energy supply.

The widely used anti-diabetes drug metformin not only reduces blood sugar but also has an anti-cancer effect. However, the metformin dose commonly used in the...

Im Focus: New Foldable Drone Flies through Narrow Holes in Rescue Missions

A research team from the University of Zurich has developed a new drone that can retract its propeller arms in flight and make itself small to fit through narrow gaps and holes. This is particularly useful when searching for victims of natural disasters.

Inspecting a damaged building after an earthquake or during a fire is exactly the kind of job that human rescuers would like drones to do for them. A flying...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

ICTM Conference 2019: Digitization emerges as an engineering trend for turbomachinery construction

12.12.2018 | Event News

New Plastics Economy Investor Forum - Meeting Point for Innovations

10.12.2018 | Event News

EGU 2019 meeting: Media registration now open

06.12.2018 | Event News

 
Latest News

Pressure tuned magnetism paves the way for novel electronic devices

18.12.2018 | Materials Sciences

New type of low-energy nanolaser that shines in all directions

18.12.2018 | Physics and Astronomy

NASA research reveals Saturn is losing its rings at 'worst-case-scenario' rate

18.12.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>