A new study by researchers at San Francisco VA Medical Center (SFVAMC) moves in on the physiological basis for the bone density loss experienced by people subjected to prolonged periods of bed rest and by astronauts who fly lengthy missions under the weightless conditions of space.
The work, conducted in rats, is an important step toward developing therapies to prevent such bone loss, says senior author Daniel Bikle, MD, co-director of the Special Diagnostic and Treatment Unit at SFVAMC and professor of medicine and dermatology at University of California, San Francisco. Lead author of the study is Takeshi Sakata, who was a postdoctoral fellow in Dr. Bikles laboratory at the time of the study and is now an orthopedic surgeon at the Kitade Hospital in Gobo, Wakayama, Japan.
The current study builds on animal work Bikle and Sakata published last year, which showed that when bones are relieved of the burden of bearing weight, bone precursor cells fail to respond to insulin-like growth factor one or IGF-I, a biochemical regulator that plays a key role in the proliferation of most cell types. Now Bikle and his team have found that this lack of response occurs because IGF-I does not activate its receptor molecule on the surface of the cells. In addition, the researchers found that the interaction failure is probably triggered by a loss of integrins, proteins found in the membranes of bone cells that enable these cells to sense mechanical changes in their immediate environment. These integrins are also known to regulate the action of growth factors in other cells. The study appears in the March issue of the Journal of Bone and Mineral Research.
Liese Greensfelder | EurekAlert!
Potential seen for tailoring treatment for acute myeloid leukemia
10.12.2018 | University of Washington Health Sciences/UW Medicine
UC San Diego researchers develop sensors to detect and measure cancer's ability to spread
06.12.2018 | University of California - San Diego
What if a sensor sensing a thing could be part of the thing itself? Rice University engineers believe they have a two-dimensional solution to do just that.
Rice engineers led by materials scientists Pulickel Ajayan and Jun Lou have developed a method to make atom-flat sensors that seamlessly integrate with devices...
Scientists at the University of Stuttgart and the Karlsruhe Institute of Technology (KIT) succeed in important further development on the way to quantum Computers.
Quantum computers one day should be able to solve certain computing problems much faster than a classical computer. One of the most promising approaches is...
New Project SNAPSTER: Novel luminescent materials by encapsulating phosphorescent metal clusters with organic liquid crystals
Nowadays energy conversion in lighting and optoelectronic devices requires the use of rare earth oxides.
Scientists have discovered the first synthetic material that becomes thicker - at the molecular level - as it is stretched.
Researchers led by Dr Devesh Mistry from the University of Leeds discovered a new non-porous material that has unique and inherent "auxetic" stretching...
Scientists from the Theory Department of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science (CFEL) in Hamburg have shown through theoretical calculations and computer simulations that the force between electrons and lattice distortions in an atomically thin two-dimensional superconductor can be controlled with virtual photons. This could aid the development of new superconductors for energy-saving devices and many other technical applications.
The vacuum is not empty. It may sound like magic to laypeople but it has occupied physicists since the birth of quantum mechanics.
10.12.2018 | Event News
06.12.2018 | Event News
03.12.2018 | Event News
10.12.2018 | Materials Sciences
10.12.2018 | Event News
07.12.2018 | Life Sciences