Malaria, which infects 600 million people in the world and leads annually to 2 million deaths, is the most widespread of infectious diseases. The pathological agent is a microscopic parasite of the Plasmodium genus which develops inside the host’s erythrocytes.
Plasmodia go through a series of asexual reproduction cycles before a transition takes place from asexual stages to production of sexual cells, the gametocytes or pre-gametes, in the host blood. The females of Anopheles, the mosquito vector, ingest blood and gametocytes during a nocturnal feed on human skin. The meal reaches the mosquito’s stomach where Plasmodium sexual reproduction takes place. An encounter and subsequent binding between a male and a female gametocyte produces a zygote which will give rise to infectious forms. These migrate up to the mosquito salivary glands. From there they are transmitted to humans during a second blood meal.
Experimental gametocyte counts in the blood ingested by mosquitoes that had bitten volunteers naturally infected with Plasmodium falciparum showed that these sexual forms are overdispersed, in other words they have a heterogeneous distribution in the mosquito stomach. Their numbers vary between the different blood meals taken on the same volunteer, a feature previously observed in the case of large parasites (macroparasites), such as microfilariae (250 microns).
Marie Guillaume | alfa
When wheels and heads are spinning - DFG research project on motion sickness in automated driving
22.05.2019 | Technische Universität Berlin
A new approach to targeting cancer cells
20.05.2019 | University of California - Riverside
Engineers at the University of Tokyo continually pioneer new ways to improve battery technology. Professor Atsuo Yamada and his team recently developed a...
With a quantum coprocessor in the cloud, physicists from Innsbruck, Austria, open the door to the simulation of previously unsolvable problems in chemistry, materials research or high-energy physics. The research groups led by Rainer Blatt and Peter Zoller report in the journal Nature how they simulated particle physics phenomena on 20 quantum bits and how the quantum simulator self-verified the result for the first time.
Many scientists are currently working on investigating how quantum advantage can be exploited on hardware already available today. Three years ago, physicists...
'Quantum technologies' utilise the unique phenomena of quantum superposition and entanglement to encode and process information, with potentially profound benefits to a wide range of information technologies from communications to sensing and computing.
However a major challenge in developing these technologies is that the quantum phenomena are very fragile, and only a handful of physical systems have been...
Working group led by physicist Professor Ulrich Nowak at the University of Konstanz, in collaboration with a team of physicists from Johannes Gutenberg University Mainz, demonstrates how skyrmions can be used for the computer concepts of the future
When it comes to performing a calculation destined to arrive at an exact result, humans are hopelessly inferior to the computer. In other areas, humans are...
Scientists develop a molecular recording tool that enables in vivo lineage tracing of embryonic cells
The beginning of new life starts with a fascinating process: A single cell gives rise to progenitor cells that eventually differentiate into the three germ...
29.04.2019 | Event News
17.04.2019 | Event News
15.04.2019 | Event News
22.05.2019 | Life Sciences
22.05.2019 | Life Sciences
22.05.2019 | Physics and Astronomy