Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hormone found to protect bones

17.02.2004


Amylin, a hormone secreted by the same cells that produce insulin in the pancreas, prevents bone loss, said Baylor College of Medicine researchers and an international group of collaborators in a report in today’s issue of the Journal of Cell Biology.



The finding may point the way toward treatments for osteoporosis, a disease of low bone mass that usually affects post-menopausal women but that is also observed in Type 1 diabetes patients, said Dr. Gèrard Karsenty, professor of molecular and human genetics at Baylor College of Medicine (BCM) in Houston and senior author.

"If osteoporosis in diabetes is associated with the absence of amylin, this finding has therapeutic implications," he said.


Amylin, a member of the calcitonin hormone family, inhibits bone loss or resorption. It is secreted by the pancreatic ß-cells at the same as insulin. Type 1 diabetics no longer produce insulin or amylin because their ß-cells no longer function. Mice who lack amylin have less bone mass than those who produce the hormone because they destroy bone more rapidly as it is seen in classical osteoporosis said Karsenty. Perhaps, he said, finding a way to replace amylin will enable physicians in the future to prevent osteoporosis in Type I diabetes and possibly in other forms of osteoporosis.

The finding extends understanding of the connection between metabolic hormones and bone mass, he said. Previously, Karsenty and his team had demonstrated that leptin, a hormone associated with weight control, affects bone formation through a brain relay.



Researchers from BCM, Beth Israel Deaconess Medical Center, Harvard Medical School, the University of Pittsburgh School of Medicine, the University of Melbourne in Australia, Hanson Institute, in South Australia and Lund University Hospital in Sweden participated in the research.

The work was supported by the National Institutes of Health, the March of Dimes, the Children’s Nutrition Research Center, the National Space Biomedical Research Institute and the National Health and Medical Research Council of Australia.

Anissa Orr | EurekAlert!
Further information:
http://research.bcm.tmc.edu/

More articles from Health and Medicine:

nachricht New nanomedicine slips through the cracks
24.04.2019 | University of Tokyo

nachricht Sugar entering the brain during septic shock causes memory loss
23.04.2019 | Rensselaer Polytechnic Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Energy-saving new LED phosphor

The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.

Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.

Im Focus: Quantum gas turns supersolid

Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.

Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

Proteins stand up to nerve cell regression

24.04.2019 | Life Sciences

New sensor detects rare metals used in smartphones

24.04.2019 | Life Sciences

Controlling instabilities gives closer look at chemistry from hypersonic vehicles

24.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>