David Watkins, researcher with the Medical School and the Wisconsin Regional Primate Research Center, studies SIV viral infection at a microscope in his research lab. Photo by: Jeff Miller
MADISON-Mutations that allow AIDS viruses to escape detection by the immune system may also hinder the viruses’ ability to grow after transmission to new hosts, scientists at the University of Wisconsin-Madison announced this week in the journal Nature Medicine.
The discovery may help researchers design vaccines that exploit the notorious mutability of HIV by training the immune system to attack the virus where it’s most vulnerable. The work appears alongside a study of HIV-infected people performed by scientists at Harvard Medical School and Oxford University. The Wisconsin study’s lead author, Thomas Friedrich, is a doctoral student working under the direction of David Watkins, professor of pathology at UW-Madison and senior scientist at the Wisconsin National Primate Research Center.
Watkins’ team produced an "escaped" AIDS virus that mimicked events that occur in HIV infection when the virus mutates to become unrecognizable to killer cells known as cytotoxic T-lymphocytes, or CTL. The researchers found that the mutant virus did not grow as well as the original strain. The mutations, while allowing the virus to escape immune recognition, had also weakened the virus. To model the transmission of escaped viruses between people, the team inoculated monkeys with the mutant virus strain. They discovered that most of the escape mutations were lost as the virus grew in the monkeys, often restoring original sequences that killer cells could recognize.
Jordana Lenon | U of Wisconsin-Madison
New method uses just a drop of blood to monitor lung cancer treatment
18.10.2018 | Osaka University
Photoactive bacteria bait may help in fight against MRSA infections
12.10.2018 | Purdue University
Scientists at the Max Planck Institute for Polymer Research (MPI-P) in Mainz (Germany) together with scientists from Dresden, Leipzig, Sofia (Bulgaria) and Madrid (Spain) have now developed and characterized a novel, metal-organic material which displays electrical properties mimicking those of highly crystalline silicon. The material which can easily be fabricated at room temperature could serve as a replacement for expensive conventional inorganic materials used in optoelectronics.
Silicon, a so called semiconductor, is currently widely employed for the development of components such as solar cells, LEDs or computer chips. High purity...
Augsburg chemists present a new technology for compressing, storing and transporting highly volatile gases in porous frameworks/New prospects for gas-powered vehicles
Storage of highly volatile gases has always been a major technological challenge, not least for use in the automotive sector, for, for example, methane or...
When we put water in a freezer, water molecules crystallize and form ice. This change from one phase of matter to another is called a phase transition. While this transition, and countless others that occur in nature, typically takes place at the same fixed conditions, such as the freezing point, one can ask how it can be influenced in a controlled way.
We are all familiar with such control of the freezing transition, as it is an essential ingredient in the art of making a sorbet or a slushy. To make a cold...
Thin organic layers provide machines and equipment with new functions. They enable, for example, tiny energy recuperators. In future, these will be installed...
Das Zusammenspiel aus Struktur und Dynamik bestimmt die Funktion von Proteinen, den molekularen Werkzeugen der Zelle. Durch Fortschritte in der...
17.10.2018 | Event News
16.10.2018 | Event News
02.10.2018 | Event News
18.10.2018 | Life Sciences
18.10.2018 | Earth Sciences
18.10.2018 | Life Sciences