A new anti-inflammatory compound called Lisofylline prevents diabetes from coming back after insulin-manufacturing islet cells are transplanted into diabetic mice, according to a new study by researchers at the University of Virginia Health System. The study is published in the January 20 issue of the journal Transplantation.
Pancreatic islet cell transplantation has become a promising treatment for type 1 diabetes in humans in recent years. But without several powerful immunosuppressive drugs, the bodys immune system would destroy the engrafted islet cells in transplant patients leading to insulin deficiency, an excess of glucose in the blood and the return of diabetes.
Lisofylline, or LSF, has the potential to help prevent this cellular destruction by preserving insulin secretion by pancreatic beta cells in the presence of autoimmune attackers called inflammatory cytokines, according to U.Va. researchers.
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