Adult stem cells have long been thought to be restricted in their potential to differentiate and regenerate tissues in which they reside. A study by Sem Phan and colleagues from the University of Michigan, in the January 15 issue of the Journal of Clinical Investigation, suggests that the collagen overproduction and deposition in the lung causing idiopathic pulmonary fibrosis may develop from cells derived from bone marrow stems cells, rather than parenchymal lung fibroblasts.
The authors induced pulmonary fibrosis in mice that had been altered with bone marrow labeled with a fluorescent green marker protein. In these mice, cells derived from bone marrow–derived stem cells fluoresce green, while those cells that reside in the lung do not. Most of the collagen-producing fibroblasts observed in the lungs of these mice fluoresced green, indicating that they were of bone marrow origin.
In an accompanying commentary Sarah Dunsmore and Steven Shapiro from Harvard Medical School discuss this new concept in pulmonary fibrosis. They state "understanding the mechanisms of engraftment will be important as clinical applications of bone marrow stem cell therapy are explored. The clinical implications of these findings are significant; for example, we might now consider bone marrow stem cell therapy to correct structural alterations in the lung." They conclude "translation of our understanding of disease pathogenesis into clinical practice will bring us closer to our real goal – improving the lives of our patients and ultimately curing disease.
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Innsbruck quantum physicists have constructed a diode for magnetic fields and then tested it in the laboratory. The device, developed by the research groups led by the theorist Oriol Romero-Isart and the experimental physicist Gerhard Kirchmair, could open up a number of new applications.
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Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
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