A multi-centre research team from the UK and the USA has discovered the first method to deliver medication directly into the encysted stage of the infectious parasites that cause toxoplasmosis and a novel target for medicines in the parasite. It has major implications for the way that we treat this devastating disease as it could lead to new medications and approaches to better tackle it. The study will be published online on November 17 by the Proceedings of the National Academy of Sciences (PNAS).
Toxoplasmosis is a parasitic infection from the apicomplexan family, which includes the causes of malaria and cryptosporidiosis. The disease is caused by a single celled organism called Toxoplasma gondii and is spread by cats and by eating undercooked meat. Toxoplasmosis is a common disease and can cause devastating problems for those with weakened immune systems, or when transmitted from mother to unborn child. It can lead to blindness, retardation and even death.
Professor David Rice, from the Department of Microbiology and Biotechnology at the University of Sheffield, was involved in the study. He explains, "Toxoplasma infections are especially difficult to treat because they recur. The disease operates in two stages, a proliferative stage and a latent stage. During the proliferative stage the infection can be treated, although there are many problems with available medicines, but the illness then progresses to a latent stage, where the cysts form that hold the parasites in a less active state. These cysts are untreatable as scientists cant get medication inside the cyst. The cysts eventually rupture and release proliferating parasites, which can cause a recurrence of the illness if the immune system is weakened and in those with eye disease. Such recurrences can cause severe damage to the eye and nervous system."
Lorna Branton | alfa
Why might reading make myopic?
18.07.2018 | Universitätsklinikum Tübingen
Unique brain 'fingerprint' can predict drug effectiveness
11.07.2018 | McGill University
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
Ultra-short, high-intensity X-ray flashes open the door to the foundations of chemical reactions. Free-electron lasers generate these kinds of pulses, but there is a catch: the pulses vary in duration and energy. An international research team has now presented a solution: Using a ring of 16 detectors and a circularly polarized laser beam, they can determine both factors with attosecond accuracy.
Free-electron lasers (FELs) generate extremely short and intense X-ray flashes. Researchers can use these flashes to resolve structures with diameters on the...
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
18.07.2018 | Life Sciences
18.07.2018 | Materials Sciences
18.07.2018 | Health and Medicine