Dr. Jerry J. Buccafusco presents his findings about the benefits of the nicotine metabolite cotinine at the November meeting of the Society for Neuroscience.
A nicotine metabolite shows promise for improving memory and protecting brain cells from diseases such as Alzheimer’s and Parkinson’s without addiction and other side effects of nicotine, says a Medical College of Georgia researcher.
Laboratory studies also indicate the metabolite cotinine may be a safe treatment for the debilitating psychotic behavior of schizophrenics, Dr. Jerry J. Buccafusco, pharmacologist and director of the MCG Alzheimer’s Research Center, says in an abstract presented at the 33rd Annual Meeting of the Society for Neuroscience in New Orleans, Nov. 8-12.
"Many people have thought the drug was an essentially inactive metabolite, but we have shown that at appropriate doses, it is memory enhancing, neuro-protective and it has antipsychotic activities," says Dr. Buccafusco, who is also a research pharmacologist at the Department of Veterans Affairs Medical Center in Augusta.
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