Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Inflammation kills new brain cells

10.11.2003


A research team at Lund University in Sweden attracted international attention a year ago by showing that new nerve cells can be generated in the brain after a stroke. However, most of these new nerve cells die rather soon. The same research team has now been able to show that an inflammation can lie behind the death of these new nerve cells, which instills hope for improved treatments for various brain disorders.



The new growth of nerve cells following epilepsy or stroke has been shown in animal studies to take place in two parts of the brain: the striatum and the hippocampus (a part that is of special importance for the memory, learning, and moods). These same areas are involved in the new formation of nerve cells in the human brain as well.

But many of the newly generated nerve cells perish rather quickly. The Lund research team, including Professor Olle Lindvall, Associate Professor Zaal Kokaia, and Doctor of Medicine Christine Ekdahl Clementson, have now been able to explain in an article in Proceedings of the National Academy of Sciences in the US that this is largely caused by an inflammatory process. They have demonstrated this in two ways: both by inducing an inflammation, which led to the death of nerve cells, and in reverse experiments by administering anti-inflammatory medicine, which reduced the number of nerve cells that died.


Inflammation of the brain occurs not only in connection with epilepsy and stroke but also in Alzheimer’s and other forms of dementia. In the future the new discoveries might lead to improved treatment of these diseases. But a great deal of research remains to be done.

“First we need to find out what function the newly formed nerve cells have. We know that the cells are of the same sort as those that are lost in a stroke, for example, but we don’t know whether the cells become fully functional to the point where they could help repair damage,” says Associate Professor Zaal Kokaia.

“We also want to learn more about the inflammatory process, which is extremely complicated. It triggers a number of different substances, and we would like to know which of them are causing cell death.”

The Lund scientists are going to pursue both of these leads in their further research.

This also has bearing on research into stem cells, which the Lund team is also working with, since transplanted cells probably also risk dying from inflammations that arise in the brain.

Ingela Björck | alfa
Further information:
http://v

More articles from Health and Medicine:

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

nachricht Breakthrough in understanding how deadly pneumococcus avoids immune defenses
13.11.2018 | University of Liverpool

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

NIH scientists illuminate causes of hepatitis b virus-associated acute liver failure

14.11.2018 | Life Sciences

The unintended consequences of dams and reservoirs

14.11.2018 | Earth Sciences

NIH scientists combine technologies to view the retina in unprecedented detail

14.11.2018 | Medical Engineering

VideoLinks
Science & Research
Overview of more VideoLinks >>>