Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Jefferson Scientists Define New Cell Type That May Lead to Clues About Kaposi’s Sarcoma

10.11.2003


For years, the origin of Kaposi’s sarcoma (KS), a rare cancer that sometimes afflicts those infected with HIV, the AIDS virus, has puzzled researchers. Now, pathologists at Jefferson Medical College may be uncovering some of its secrets.



George Murphy, M.D., professor of pathology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, and Masatoshi Deguchi, M.D., visiting scientist from Tohuku University in Sendai, Japan, have created a mouse model that resembles an early form of KS. To accomplish this, they have grown and characterized a line of mouse skin cells in the laboratory that they believe are analogous to the cells that go awry early on in human KS.

The type of cell, termed a “dermal dendrocyte,” increases dramatically in number in tumors in early human KS, he says. When Dr. Murphy and his co-workers injected the dermal dendrocytes directly into normal mouse skin, the injected areas developed features similar to human KS.


The findings may lead to insights into the origins of other diseases, such as scleroderma, abnormal wound healing and a chronic form of graft-versus-host-disease involved in bone marrow transplantation.

Dr. Murphy and his group report their findings November 1 in the American Journal of Pathology.

According to Dr. Murphy, KS usually begins as one of many bruise-like areas on the skin that develops over time into tumors. KS may also affect internal organs, particularly in AIDS, and may be fatal.

Dermal dendrocytes – which have been known to exist only since 1985 – may play roles in wound healing or in the immune system. There is evidence for both.

“It’s interesting that in AIDS, it is occurring in the setting of immune disease, and involves an immune cell proliferating abnormally,” he says. What’s more, “KS can occur in areas of trauma,” he says, “and a wound healing cell might be proliferating abnormally” in such conditions.

When the dermal dendrocyte was first discovered in 1985, scientists found that the cell type contained a blood clotting factor. One explanation for this might be that the cell secretes the clotting factor to help form initial blood clots after injury and begin the healing process.

“The problem of understanding the biology and pathogenesis of KS and the dermal dendrocytes is that we’ve never had a purified cell line to study until now,” Dr. Murphy. “Now we have a cell line that is purified and expresses a blood clotting factor.”

“We now have an important tool to study KS not only experimentally because we have the early cell that we think contributes to the pathogenesis of the disease,” he says. “We also have the cell that we could never study in a purified manner before that might have a lot to do with abnormal wound healing and diseases such as scleroderma. It opens up a new area of inquiry.”

“It’s a potential mouse model for KS,” Dr. Murphy says. “What are missing are the other co-factors that would lead the evolution of the early lesion to the late lesion that kills patients.” These could include immunodeficiency, HIV or other viruses such as herpesvirus-8, which has been found in KS.

“Now, the mouse model that we have established can be studied by introducing these other factors and see if they can induce these early lesions to behave like the natural history of the human lesion.”

Steven Benowitz | TJUH
Further information:
http://www.jeffersonhospital.org/news/e3front.dll?durki=17237

More articles from Health and Medicine:

nachricht The genes are not to blame
20.07.2018 | Technische Universität München

nachricht Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Future electronic components to be printed like newspapers

A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.

The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...

Im Focus: First evidence on the source of extragalactic particles

For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.

To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...

Im Focus: Magnetic vortices: Two independent magnetic skyrmion phases discovered in a single material

For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.

Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...

Im Focus: Breaking the bond: To take part or not?

Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.

A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...

Im Focus: New 2D Spectroscopy Methods

Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.

"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Leading experts in Diabetes, Metabolism and Biomedical Engineering discuss Precision Medicine

13.07.2018 | Event News

Conference on Laser Polishing – LaP: Fine Tuning for Surfaces

12.07.2018 | Event News

11th European Wood-based Panel Symposium 2018: Meeting point for the wood-based materials industry

03.07.2018 | Event News

 
Latest News

A smart safe rechargeable zinc ion battery based on sol-gel transition electrolytes

20.07.2018 | Power and Electrical Engineering

Reversing cause and effect is no trouble for quantum computers

20.07.2018 | Information Technology

Princeton-UPenn research team finds physics treasure hidden in a wallpaper pattern

20.07.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>