Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone cement only controls bacteria for a few days after the operation

10.10.2003


Dutch research has revealed that bone cement containing antibiotics can effectively control infections around prostheses but only during the first few days after the implantation. For the past 30 years bone cement, which affixes hip and knee prostheses to the bone, has contained antibiotics and from the start, the usefulness of this has been contested.



In a laboratory set-up, Hans Hendriks discovered that in the immediate vicinity of the antibiotic-containing bone cement, the antibiotic concentrations are particularly high. However, this is predominantly during the first few days after the application of the cement and the long-term release of the antibiotic seems to be less effective.

Hendriks investigated the release of antibiotics under simulated real-life conditions. He first of all investigated the antibiotic concentration in the cavity between the surface of the bone and the bone cement. In the human body this cavity is about 0.2 mm wide.


The antibiotic concentrations in the cavity were found to be 1000 times higher than the lethal dose for most bacteria. Experiments with different bacterial species led Hendriks to conclude that virtually no bacteria could survive in this environment. Three weeks later, the concentration of antibiotics had decreased to the extent that increasingly fewer bacteria were inhibited by these.

Placing the bone cement under stress did not affect the release of antibiotics. Walking on a cemented prosthesis results in the bone cement being subjected to periodic stress. Small cracks can arise as a consequence of this. As the surface of such a crack has not previously been in direct contact with body fluids it could form a new surface for the release of the antibiotic. Using an experimental set-up, Hendriks demonstrated that no new release occurs even after 5 to 10 years of walking around on a prosthesis.

For the past 30 years, bone cement has contained antibiotics to prevent and cure infections around implants. However, opinions were divided with respect to the effectiveness of this treatment as well as the associated risks. Furthermore, the exact mechanism by which the cement released the antibiotics was unclear. However, it has been established that more than eighty percent of the antibiotics can still be found in the bone cement years later. Knowledge about the release of the antibiotics could contribute to the development of new antibiotic carriers to control infections in orthopaedic surgery.

Sonja Jacobs | alfa
Further information:
http://www.nwo.nl

More articles from Health and Medicine:

nachricht Spread of deadly eye cancer halted in cells and animals
13.11.2018 | Johns Hopkins Medicine

nachricht Breakthrough in understanding how deadly pneumococcus avoids immune defenses
13.11.2018 | University of Liverpool

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

Im Focus: Coping with errors in the quantum age

Physicists at ETH Zurich demonstrate how errors that occur during the manipulation of quantum system can be monitored and corrected on the fly

The field of quantum computation has seen tremendous progress in recent years. Bit by bit, quantum devices start to challenge conventional computers, at least...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

The dawn of a new era for genebanks - molecular characterisation of an entire genebank collection

13.11.2018 | Life Sciences

Fish recognize their prey by electric colors

13.11.2018 | Life Sciences

Ultrasound Connects

13.11.2018 | Awards Funding

VideoLinks
Science & Research
Overview of more VideoLinks >>>