An engineered mouse, already known to be immune to the weight gain ramifications of a high-calorie, high-fat diet, now seems able to resist the onset of diabetes.
Professor of biochemistry and nutritional sciences James Ntambi holds two mice in his research lab and points to the mouse that is missing a SCD-1 gene and is significantly thinner than the normal mouse at right. Ntambi recently found that subracting a single gene, SCD-1, from the genome of a mouse creates an animal that can eat a rich, high-fat diet without gaining weight or risking the complications of diabetes.
Photo by: Jeff Miller
Date: August 2002
The mouse, stripped of a gene known as SCD-1, is apparently impervious to the negative effects of the type of diet that, for many people, has significant health and social consequences.
"We think this animal model may be protected against diabetes," says James Ntambi, a University of Wisconsin-Madison professor of biochemistry and Steenbock professor of nutrition, and the senior author of a report describing the remarkable mouse in this weeks (Sept. 1) online editions of the Proceedings of the National Academy of Sciences (PNAS).
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