Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New brain cancer treatment extends survival for more patients

21.08.2003


Patients stay home, take a pill instead of IV chemotherapy



A doctor at the James P. Wilmot Cancer Center has developed a new brain cancer treatment that, in a pilot study, shows promise at keeping more patients alive longer than the best current standard treatments for the disease. Preliminary findings were presented recently at the American Society of Clinical Oncology annual meeting in Chicago, and now the study is continuing for adults and will be expanded to include children nationwide.

The treatment is a combination of two cancer-killing drugs that can be taken orally as pills, making it easier on those patients who have already undergone difficult surgery, radiation or traditional, intravenous chemotherapy.


"It’s not a miracle, but it’s a piece of the struggle against brain cancer," says David N. Korones, M.D., principal investigator and associate professor of Pediatrics, Oncology, and Neurology at the University of Rochester Medical Center. "It’s a new, somewhat innovative approach that has merit and offers better tolerance than traditional chemotherapy. It makes life much easier for these patients. Patients can stay home and simply take a pill, instead of coming into the hospital for several hours to be tethered to an IV."

Korones is the first to investigate the effectiveness of temozolomide and etoposide, given together for patients with recurrent malignant glioma, the most common brain tumor in adults. Each of the drugs, which have been approved by the Food and Drug Administration, has been used separately with some success. But Korones noticed that laboratory data showed synergies between the two medications, and he theorized they may work better in tandem.

Among the 24 adult patients he has followed so far, 16 percent saw their tumors shrink and 35 percent were stable with no disease progression after six months, compared to 10-20 percent of patients who stabilize after traditional chemotherapy. The results are encouraging, he says; the median survival time for brain cancer that recurs is just six months.

The medications have been reasonably well tolerated. With no need to come into the hospital for IV therapy, patients can stay home and report weekly for blood tests. In a pilot study of four children aged 10 or older, using doses comparable to the adults, Korones also noted that side effects were minimal, and the tumors shrunk dramatically.

Brain cancer consists of a mass of cells that do not belong there. But for cancer-fighting drugs to reach the mass, first they must be able to pass through the blood-brain barrier, which is cleverly designed to keep out toxins. Temozolomide and etoposide are effective at passing through the barrier, Korones says.


Schering-Plough Inc., manufacturer of temozolomide, is funding the research. With Korones as the principal investigator, other institutions participating are: Rochester General Hospital’s Lipson Cancer and Blood Center; Roswell Park Cancer Institute, Buffalo; Dent Neurologic Institute, Buffalo; SUNY Health Science Center, Syracuse; The Brain Tumor Center at Duke University Medical Center, Durham, N.C.

Leslie Orr | EurekAlert!
Further information:
http://www.urmc.rochester.edu/

More articles from Health and Medicine:

nachricht New nanomedicine slips through the cracks
24.04.2019 | University of Tokyo

nachricht Sugar entering the brain during septic shock causes memory loss
23.04.2019 | Rensselaer Polytechnic Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Energy-saving new LED phosphor

The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.

Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.

Im Focus: Quantum gas turns supersolid

Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.

Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

Proteins stand up to nerve cell regression

24.04.2019 | Life Sciences

New sensor detects rare metals used in smartphones

24.04.2019 | Life Sciences

Controlling instabilities gives closer look at chemistry from hypersonic vehicles

24.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>