Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Aspirin could reduce the risk of deadly infections

18.07.2003


Adding to the long list of the benefits of aspirin, researchers have found that it is responsible for reducing toxic bacteria associated with serious infections. A study led by Dartmouth Medical School describes how salicylic acid-produced when the body breaks down aspirin-disrupts the bacteria´s ability to adhere to host tissue, reducing the threat of deadly infections.



The investigation, which appears in the July 15 issue of the Journal of Clinical Investigation, focused on the bacterium Staphylococcus aureus, and its role in infections in animal tissue. S. aureus is a leading cause of serious systemic (often referred to as staph) infections and abscesses.

"Our research shows that salicylic acid, a byproduct of aspirin, impacted the stress system of the bacteria and reduced its ability to cause infection," said lead author Dr. Ambrose Cheung, a professor of microbiology and immunology at Dartmouth Medical School.


By disrupting this stress system, aspirin reduced the bacteria´s capacity to adhere to host tissue. In addition, the salicylic acid disrupted the ability of S. aureus to produce toxins, which the bacteria require to propagate and spread to other tissue. As a result, the animals treated with aspirin have smaller abscesses and they have fewer number of bacteria in the infection. Aspirin did not cure it, notes Cheung, but it reduced the ability of the bacteria to cause infection.

The S. aureus bacteria are also responsible for sepsis, a blood poisoning disease that strikes 750,000 people in the US annually and is the leading cause of death in America´s non-coronary intensive care units. Cases of sepsis are growing in number each year and are becoming increasingly resistant to antibiotics, making aspirin a possibly invaluable option for treatment.

"The fact that aspirin has been used for pain treatment, to reduce mortality due to heart attacks, and can possibly reduce the risks of infection is incredible," said Cheung. "We look forward to conducting future tests with aspirin in conjunction with antibiotic therapy."

Andy Nordhoff | EurekAlert!
Further information:
http://www.dartmouth.edu

More articles from Health and Medicine:

nachricht Safer viruses for vaccine research and diagnosis
12.12.2019 | University of Queensland

nachricht Illinois team develops first of a kind in-vitro 3D neural tissue model
11.12.2019 | University of Illinois College of Engineering

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly charged ion paves the way towards new physics

In a joint experimental and theoretical work performed at the Heidelberg Max Planck Institute for Nuclear Physics, an international team of physicists detected for the first time an orbital crossing in the highly charged ion Pr⁹⁺. Optical spectra were recorded employing an electron beam ion trap and analysed with the aid of atomic structure calculations. A proposed nHz-wide transition has been identified and its energy was determined with high precision. Theory predicts a very high sensitivity to new physics and extremely low susceptibility to external perturbations for this “clock line” making it a unique candidate for proposed precision studies.

Laser spectroscopy of neutral atoms and singly charged ions has reached astonishing precision by merit of a chain of technological advances during the past...

Im Focus: Ultrafast stimulated emission microscopy of single nanocrystals in Science

The ability to investigate the dynamics of single particle at the nano-scale and femtosecond level remained an unfathomed dream for years. It was not until the dawn of the 21st century that nanotechnology and femtoscience gradually merged together and the first ultrafast microscopy of individual quantum dots (QDs) and molecules was accomplished.

Ultrafast microscopy studies entirely rely on detecting nanoparticles or single molecules with luminescence techniques, which require efficient emitters to...

Im Focus: How to induce magnetism in graphene

Graphene, a two-dimensional structure made of carbon, is a material with excellent mechanical, electronic and optical properties. However, it did not seem suitable for magnetic applications. Together with international partners, Empa researchers have now succeeded in synthesizing a unique nanographene predicted in the 1970s, which conclusively demonstrates that carbon in very specific forms has magnetic properties that could permit future spintronic applications. The results have just been published in the renowned journal Nature Nanotechnology.

Depending on the shape and orientation of their edges, graphene nanostructures (also known as nanographenes) can have very different properties – for example,...

Im Focus: Electronic map reveals 'rules of the road' in superconductor

Band structure map exposes iron selenide's enigmatic electronic signature

Using a clever technique that causes unruly crystals of iron selenide to snap into alignment, Rice University physicists have drawn a detailed map that reveals...

Im Focus: Developing a digital twin

University of Texas and MIT researchers create virtual UAVs that can predict vehicle health, enable autonomous decision-making

In the not too distant future, we can expect to see our skies filled with unmanned aerial vehicles (UAVs) delivering packages, maybe even people, from location...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

The Future of Work

03.12.2019 | Event News

First International Conference on Agrophotovoltaics in August 2020

15.11.2019 | Event News

Laser Symposium on Electromobility in Aachen: trends for the mobility revolution

15.11.2019 | Event News

 
Latest News

Safer viruses for vaccine research and diagnosis

12.12.2019 | Health and Medicine

NTU Singapore scientists convert plastics into useful chemicals using su

12.12.2019 | Life Sciences

Studies show integrated strategies work best for buffelgrass control

12.12.2019 | Agricultural and Forestry Science

VideoLinks
Science & Research
Overview of more VideoLinks >>>