With 15,000 tons produced each year for batteries, alloys, and pigments, the heavy metal cadmium is one of the most serious environmental pollutants. Chronic exposure can induce kidney damage and bone disease and is thought to cause cancer. A study in the August issue of Nature Medicine now shows that cadmium mimics the effects of estrogen, and suggests that even at relatively low doses cadmium might have wide-ranging effects on the body.
Mary Beth Martin and colleagues report that, in rats, cadmium induces several well-known estrogenic responses. These included increased uterine weight, changes in the endometrial lining and increased density of the epithelia of the mammary gland. Moreover, in utero exposure to cadmium affected mammary gland development and onset of puberty in female offspring. The results provide solid evidence that cadmium has estrogenic effects in the whole animal, and follow up on earlier studies reporting that cadmium and other heavy metals such as nickel interact with the estrogen receptor. The new data also broaden the toxic repertoire of cadmium, which is a known kidney toxin, and was recently shown (Jin et al., Nat. Genet. 34, 326–329; 2003) to impair DNA repair processes in yeast.
The investigators did not perform dose-response studies but they found that cadmium induced potent estrogenic responses in rats at doses (5–10 micrograms per kilogram total weight) comparable to the Provisional Tolerable Weekly Intake recommended by the World Health Organization (7 micrograms per kilogram per week). In addition to pinpointing another mechanism for some of cadmium’s effects, the new data could call into question current regulatory standards for cadmium exposure.
Jo Webber | alfa
The genes are not to blame
20.07.2018 | Technische Universität München
Targeting headaches and tumors with nano-submarines
20.07.2018 | Universitätsmedizin der Johannes Gutenberg-Universität Mainz
A new manufacturing technique uses a process similar to newspaper printing to form smoother and more flexible metals for making ultrafast electronic devices.
The low-cost process, developed by Purdue University researchers, combines tools already used in industry for manufacturing metals on a large scale, but uses...
For the first time ever, scientists have determined the cosmic origin of highest-energy neutrinos. A research group led by IceCube scientist Elisa Resconi, spokesperson of the Collaborative Research Center SFB1258 at the Technical University of Munich (TUM), provides an important piece of evidence that the particles detected by the IceCube neutrino telescope at the South Pole originate from a galaxy four billion light-years away from Earth.
To rule out other origins with certainty, the team led by neutrino physicist Elisa Resconi from the Technical University of Munich and multi-wavelength...
For the first time a team of researchers have discovered two different phases of magnetic skyrmions in a single material. Physicists of the Technical Universities of Munich and Dresden and the University of Cologne can now better study and understand the properties of these magnetic structures, which are important for both basic research and applications.
Whirlpools are an everyday experience in a bath tub: When the water is drained a circular vortex is formed. Typically, such whirls are rather stable. Similar...
Physicists working with Roland Wester at the University of Innsbruck have investigated if and how chemical reactions can be influenced by targeted vibrational excitation of the reactants. They were able to demonstrate that excitation with a laser beam does not affect the efficiency of a chemical exchange reaction and that the excited molecular group acts only as a spectator in the reaction.
A frequently used reaction in organic chemistry is nucleophilic substitution. It plays, for example, an important role in in the synthesis of new chemical...
Optical spectroscopy allows investigating the energy structure and dynamic properties of complex quantum systems. Researchers from the University of Würzburg present two new approaches of coherent two-dimensional spectroscopy.
"Put an excitation into the system and observe how it evolves." According to physicist Professor Tobias Brixner, this is the credo of optical spectroscopy....
13.07.2018 | Event News
12.07.2018 | Event News
03.07.2018 | Event News
20.07.2018 | Power and Electrical Engineering
20.07.2018 | Information Technology
20.07.2018 | Materials Sciences