Researchers at the University of California, San Diego (UCSD) School of Medicine have shown that a non-steroidal anti-inflammatory drug (NSAID) applied as a cream directly to the skin is safe and effective in lessening muscle soreness experienced 24 to 48 hours following exercise, when soreness reaches its peak. In addition, the direct application bypasses the internal body-route taken by oral medications, thus avoiding unpleasant side effects sometimes experienced with NSAIDs.
In a study published in the July issue of the Clinical Journal of Sport Medicine, the investigators compared a transdermal (cream) version of an NSAID called ketoprofen against a cream version of a placebo, in a study with 32 healthy males between the ages of 18 and 35 years. Women were not included to avoid fertility or pregnancy complications.
At 48 hours following exercise, the study volunteers who used the NSAID cream reported 37 to 45 percent less muscle soreness than those who used a placebo.
Sue Pondrom | UCSD News
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