Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Sequence of human chromosome 7 is fine-tuned and finished

10.07.2003


Researchers at Washington University School of Medicine in St. Louis, in collaboration with investigators at five other centers, have finished sequencing human chromosome 7. The findings are published in the July 10 issue of the journal Nature.



Chromosome 7 is the largest human chromosome to be sequenced so far. The analysis revealed that the chromosome has about 1,150 genes and 940 so-called pseudogenes, stretches of DNA that closely resemble genes but contain some genetic change that prevents them from functioning like a gene. The biological significance of pseudogenes is unknown.

"This work completes another volume in the genome encyclopedia at a high standard of quality and a high degree of continuity," says principal investigator Richard K. Wilson, Ph.D., director of Washington University’s Genome Sequencing Center and professor of genetics and of molecular microbiology. "The sequence for chromosome 7 will be very useful for follow-up studies that have a medical application."


The work may benefit research in cystic fibrosis, deafness, B-cell lymphoma and other cancers, genes for which are found on chromosome 7. Also found there is the gene for P-glycoprotein, a protein that enables cancer cells to resist anticancer drugs. Other important genes found on chromosome 7 include those that help control cell division and cell death, genes for taste and smell receptors and those involved in immune responses.

Chromosome 7 also has a relatively centrally located centromere, a small region found on all chromosomes that is important during cell division. Centromeres on other chromosomes sequenced so far are located near the tip of the chromosome, like a knob. The centromere on chromosome 7 divides the chromosome into a short arm and a long arm, both of which carry many genes. Sequencing proceeded from each end toward the centromere.

The centromere itself contains many short repetitive DNA sequences and few, if any, genes.

"We got in close to the centromere and characterized those repeat sequences for the first time," Wilson says.

The most challenging region of the chromosome to sequence was that containing genes for Williams-Beuren syndrome (WBS), a rare genetic disorder characterized by mild mental retardation, unusual facial appearance and a narrowing of the aorta, the major artery leaving the heart. The WBS region was difficult to decipher because it contains large segments DNA with many duplicated genes, and the number of duplicated genes differs among individuals. Children with WBS are missing long stretches of these duplicated genes.

"It seems that multiple copies of these genes are necessary for normal development, and if any are lost, developmental abnormalities occur," Wilson says. "People who study this disease may find the chromosome 7 sequence data very helpful."

Next, Wilson and his colleagues will resequence certain genes on chromosome 7 from people with acute leukemia to better understand the genetic changes that give rise to the malignancy.


Hillier LW, Fulton RS, Fulton LA. et al. The DNA sequence of human chromosome 7. Nature, July 10, 2003.

Darrell E. Ward | EurekAlert!
Further information:
http://medinfo.wustl.edu/

More articles from Health and Medicine:

nachricht Purdue cancer identity technology makes it easier to find a tumor's 'address'
16.11.2018 | Purdue University

nachricht Microgel powder fights infection and helps wounds heal
14.11.2018 | Michigan Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: UNH scientists help provide first-ever views of elusive energy explosion

Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.

Magnetic reconnection has remained a bit of a mystery to scientists. They know it exists and have documented the effects that the energy explosions can...

Im Focus: A Chip with Blood Vessels

Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.

Cultivating human cells in the Petri dish is not a big challenge today. Producing artificial tissue, however, permeated by fine blood vessels, is a much more...

Im Focus: A Leap Into Quantum Technology

Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.

In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...

Im Focus: Research icebreaker Polarstern begins the Antarctic season

What does it look like below the ice shelf of the calved massive iceberg A68?

On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.

Im Focus: Penn engineers develop ultrathin, ultralight 'nanocardboard'

When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure

Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

“3rd Conference on Laser Polishing – LaP 2018” Attracts International Experts and Users

09.11.2018 | Event News

On the brain’s ability to find the right direction

06.11.2018 | Event News

European Space Talks: Weltraumschrott – eine Gefahr für die Gesellschaft?

23.10.2018 | Event News

 
Latest News

Purdue cancer identity technology makes it easier to find a tumor's 'address'

16.11.2018 | Health and Medicine

Good preparation is half the digestion

16.11.2018 | Life Sciences

Microscope measures muscle weakness

16.11.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>