A collaboration of scientists mainly from the Fred Hutchinson Cancer Center and at the University of Washington (Seattle) has made an important discovery linking the powerful cancer-causing oncogene, myc, with the gene behind the premature aging disease, Werner syndrome. Their finding reveals that the MYC oncoprotein turns-on Werner syndrome gene expression, and posits the Werner syndrome gene as a potentially important participant in MYC-induced tumorigenesis.
Werner syndrome is a rare genetic disorder characterized by the appearance of old age beginning after puberty. It is caused by mutations in the Werner syndrome gene (WRN), which resides on the short arm of human chromosome 8. The WRN gene encodes a DNA helicase (an enzyme that unwinds DNA) involved in DNA replication and repair.
As published in the July 1 issue of Genes & Development, Dr. Carla Grandori and colleagues have discovered that WRN expression is regulated by the MYC oncoprotein, which is implicated in about one third of all human cancers.
Heather Cosel | EurekAlert!
Purdue cancer identity technology makes it easier to find a tumor's 'address'
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Microgel powder fights infection and helps wounds heal
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Researchers at the University of New Hampshire have captured a difficult-to-view singular event involving "magnetic reconnection"--the process by which sparse particles and energy around Earth collide producing a quick but mighty explosion--in the Earth's magnetotail, the magnetic environment that trails behind the planet.
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Biochips have been developed at TU Wien (Vienna), on which tissue can be produced and examined. This allows supplying the tissue with different substances in a very controlled way.
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Faster and secure data communication: This is the goal of a new joint project involving physicists from the University of Würzburg. The German Federal Ministry of Education and Research funds the project with 14.8 million euro.
In our digital world data security and secure communication are becoming more and more important. Quantum communication is a promising approach to achieve...
On Saturday, 10 November 2018, the research icebreaker Polarstern will leave its homeport of Bremerhaven, bound for Cape Town, South Africa.
When choosing materials to make something, trade-offs need to be made between a host of properties, such as thickness, stiffness and weight. Depending on the application in question, finding just the right balance is the difference between success and failure
Now, a team of Penn Engineers has demonstrated a new material they call "nanocardboard," an ultrathin equivalent of corrugated paper cardboard. A square...
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16.11.2018 | Life Sciences
16.11.2018 | Life Sciences