Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Donor cells from new source ignored by the immune system

18.06.2003


Transplant research takes a hopeful step



Researchers at Kansas State University have successfully transplanted cells from one species to another without triggering an immune system rejection response or requiring drugs to suppress the immune system.

This hopeful news for transplant medicine is reported in the online edition of the journal Experimental Neurology, published by Elsevier.


Researchers transplanted umbilical cord matrix stem cells from a pig into the brain of a live rat, and for reasons they as yet do not understood, the recipient’s immune system did not detect nor reject the foreign cells, which survived for more than six weeks. No drugs were used to suppress the immune response.

A subset of the transplanted stem cells responded to the chemical environment of the brain and began to develop as nervous system cells. This transition of cell type in a living animal is the first indication that umbilical cord matrix stem cells could be useful therapeutically.

"Specifically, the umbilical cord matrix cell source may offer us a basis for treating nervous system disorders like Parkinson’s disease," said neuroscientist Mark Weiss, lead investigator and first author of the study.

Developing effective treatments for Parkinson’s and other nervous system disorders depends on scientists identifying a source of neural progenitor cells that can be transplanted without complications.

"Transplantation of Porcine Umbilical Cord Matrix Cells into the Rat Brain" is co-authored with veterinary and animal science researchers Kathy Mitchell, J.E. Hix, S. Medicetty, S.Z. El-Zarkouny, David Grieger and Deryl Troyer.

"We are reporting three lines of evidence indicating that stem cells from the umbilical cord matrix do not trigger an immune system response when they are transplanted across species," said Weiss. "We do not understand yet what enables the donor UCM cells to exist below the radar of the recipient’s immune system," he added.

Rejection of transplanted material is an immune system response that poses a serious limitation for successful cell and organ transplants.

To grapple with this vexing problem, transplant recipients typically receive massive doses of immunosuppressive drugs in the hope of buying time for grafted cell or organ to survive and take hold.

Pig umbilical cord matrix cells appear to be ignored by the immune system when implanted into rat brain, which makes the cells potentially useful as future therapy. In similar studies, K-State researchers are now testing human umbilical cord matrix cells for transplant suitability. Evidence already exists that the human umbilical cord matrix cells can differentiate into nervous system tissue.

In a January 2003 paper in the journal Stem Cells, the K-State team reported that umbilical cord matrix cells from both animal and human are a type of stem cell that can be induced in vitro to differentiate into neurons and glia, the primary nervous system tissues.

Based on that discovery, the current project was designed to answer two important questions -- could umbilical cord matrix cells survive transplantation from one species into another, and if they survive, could they differentiate from donor stem cell status to become nervous system cells?

Mark Weiss | EurekAlert!
Further information:
http://www.ksu.edu/

More articles from Health and Medicine:

nachricht Inselspital: Fewer CT scans needed after cerebral bleeding
20.03.2019 | Universitätsspital Bern

nachricht Building blocks for new medications: the University of Graz is seeking a technology partner
19.03.2019 | Karl-Franzens-Universität Graz

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The taming of the light screw

DESY and MPSD scientists create high-order harmonics from solids with controlled polarization states, taking advantage of both crystal symmetry and attosecond electronic dynamics. The newly demonstrated technique might find intriguing applications in petahertz electronics and for spectroscopic studies of novel quantum materials.

The nonlinear process of high-order harmonic generation (HHG) in gases is one of the cornerstones of attosecond science (an attosecond is a billionth of a...

Im Focus: Magnetic micro-boats

Nano- and microtechnology are promising candidates not only for medical applications such as drug delivery but also for the creation of little robots or flexible integrated sensors. Scientists from the Max Planck Institute for Polymer Research (MPI-P) have created magnetic microparticles, with a newly developed method, that could pave the way for building micro-motors or guiding drugs in the human body to a target, like a tumor. The preparation of such structures as well as their remote-control can be regulated using magnetic fields and therefore can find application in an array of domains.

The magnetic properties of a material control how this material responds to the presence of a magnetic field. Iron oxide is the main component of rust but also...

Im Focus: Self-healing coating made of corn starch makes small scratches disappear through heat

Due to the special arrangement of its molecules, a new coating made of corn starch is able to repair small scratches by itself through heat: The cross-linking via ring-shaped molecules makes the material mobile, so that it compensates for the scratches and these disappear again.

Superficial micro-scratches on the car body or on other high-gloss surfaces are harmless, but annoying. Especially in the luxury segment such surfaces are...

Im Focus: Stellar cartography

The Potsdam Echelle Polarimetric and Spectroscopic Instrument (PEPSI) at the Large Binocular Telescope (LBT) in Arizona released its first image of the surface magnetic field of another star. In a paper in the European journal Astronomy & Astrophysics, the PEPSI team presents a Zeeman- Doppler-Image of the surface of the magnetically active star II Pegasi.

A special technique allows astronomers to resolve the surfaces of faraway stars. Those are otherwise only seen as point sources, even in the largest telescopes...

Im Focus: Heading towards a tsunami of light

Researchers at Chalmers University of Technology and the University of Gothenburg, Sweden, have proposed a way to create a completely new source of radiation. Ultra-intense light pulses consist of the motion of a single wave and can be described as a tsunami of light. The strong wave can be used to study interactions between matter and light in a unique way. Their research is now published in the scientific journal Physical Review Letters.

"This source of radiation lets us look at reality through a new angle - it is like twisting a mirror and discovering something completely different," says...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

International Modelica Conference with 330 visitors from 21 countries at OTH Regensburg

11.03.2019 | Event News

Selection Completed: 580 Young Scientists from 88 Countries at the Lindau Nobel Laureate Meeting

01.03.2019 | Event News

LightMAT 2019 – 3rd International Conference on Light Materials – Science and Technology

28.02.2019 | Event News

 
Latest News

Solving the efficiency of Gram-negative bacteria

22.03.2019 | Life Sciences

Bacteria bide their time when antibiotics attack

22.03.2019 | Life Sciences

Open source software helps researchers extract key insights from huge sensor datasets

22.03.2019 | Information Technology

VideoLinks
Science & Research
Overview of more VideoLinks >>>