Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Curacyte scientists discover new anti-tumour agents

17.06.2003


Curacyte AG, a Munich-based drug development company focused on novel treatments of inflammatory diseases, thrombotic disorders and cancer has announced today that its scientists have discovered a series of novel small molecule inhibitors of matriptase, a trypsin-like serine protease. Matriptase is an important mediator in the degradation of the extracellular matrix, a process which plays a key role during metastasis. Inhibiting this key enzyme produced by tumor cells might provide a route to prevent tumor metastasis and invasive growth. This compound series thus offers potential as novel anti-tumor agents for the treatment of metastatic malignancies and Curacyte will now move this program into pre-clinical development.



Since the discovery of the gene in 1999, matriptase has increasingly gained attention as a potential biological target for inhibiting tumor spread. Today, matriptase is recognized as an innovative anti-cancer target. In in vitro assays, the Curacyte inhibitor series exhibit excellent affinity and selectivity towards the target and a pharmacokinetic profile that supports their use as pharmaceutically active substances.

Dr. Helmut Giersiefen, Chief Executive Officer of Curacyte AG, commented on the recent scientific success:


"The discovery of the matriptase inhibitors corroborates the validity and value of our protease technology. Based on our proprietary inhibitor libraries and our competence with respect to the chemistry of these substances, we have identified a series of novel potential anti-tumor agents, enabling us to move another important project into preclinical development. We will continue to derive therapeutically valuable applications from our protease technology that we can leverage with pharmaceutical partners."

Curacyte pursues the development of its protease technology in close collaboration with the Center of Vascular Biology and Medicine of the University of Jena (Germany) under the leadership of Dr. Jörg Stürzebecher, a well-known pioneer in the area of synthetic inhibitors of serine proteases.

"We are very proud of our collaboration with Curacyte," commented Dr. Stürzebecher. "The successful development of these matriptase inhibitors was possible by combining our knowledge of the structure-function relationship of protease inhibitors that we gained over decades with the competence in drug discovery and pharmaceutical development provided by Curacyte. Our collaboration on protease inhibitors, including matriptase has been ongoing for over two years and establishes a benchmark for the fruitful synergies that can be created by bringing together academic and commercial competencies."

Sue Charles | alfa
Further information:
http://www.curacyte.com

More articles from Health and Medicine:

nachricht Diabetes mellitus: A risk factor for early colorectal cancer
27.05.2020 | Nationales Centrum für Tumorerkrankungen (NCT) Heidelberg

nachricht Ultra-thin fibres designed to protect nerves after brain surgery
27.05.2020 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Small Protein, Big Impact

In meningococci, the RNA-binding protein ProQ plays a major role. Together with RNA molecules, it regulates processes that are important for pathogenic properties of the bacteria.

Meningococci are bacteria that can cause life-threatening meningitis and sepsis. These pathogens use a small protein with a large impact: The RNA-binding...

Im Focus: K-State study reveals asymmetry in spin directions of galaxies

Research also suggests the early universe could have been spinning

An analysis of more than 200,000 spiral galaxies has revealed unexpected links between spin directions of galaxies, and the structure formed by these links...

Im Focus: New measurement exacerbates old problem

Two prominent X-ray emission lines of highly charged iron have puzzled astrophysicists for decades: their measured and calculated brightness ratios always disagree. This hinders good determinations of plasma temperatures and densities. New, careful high-precision measurements, together with top-level calculations now exclude all hitherto proposed explanations for this discrepancy, and thus deepen the problem.

Hot astrophysical plasmas fill the intergalactic space, and brightly shine in stellar coronae, active galactic nuclei, and supernova remnants. They contain...

Im Focus: Biotechnology: Triggered by light, a novel way to switch on an enzyme

In living cells, enzymes drive biochemical metabolic processes enabling reactions to take place efficiently. It is this very ability which allows them to be used as catalysts in biotechnology, for example to create chemical products such as pharmaceutics. Researchers now identified an enzyme that, when illuminated with blue light, becomes catalytically active and initiates a reaction that was previously unknown in enzymatics. The study was published in "Nature Communications".

Enzymes: they are the central drivers for biochemical metabolic processes in every living cell, enabling reactions to take place efficiently. It is this very...

Im Focus: New double-contrast technique picks up small tumors on MRI

Early detection of tumors is extremely important in treating cancer. A new technique developed by researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from normal tissue. The work is published May 25 in the journal Nature Nanotechnology.

researchers at the University of California, Davis offers a significant advance in using magnetic resonance imaging to pick out even very small tumors from...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Dresden Nexus Conference 2020: Same Time, Virtual Format, Registration Opened

19.05.2020 | Event News

Aachen Machine Tool Colloquium AWK'21 will take place on June 10 and 11, 2021

07.04.2020 | Event News

International Coral Reef Symposium in Bremen Postponed by a Year

06.04.2020 | Event News

 
Latest News

Why developing nerve cells can take a wrong turn

04.06.2020 | Life Sciences

The broken mirror: Can parity violation in molecules finally be measured?

04.06.2020 | Physics and Astronomy

Innocent and highly oxidizing

04.06.2020 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>