Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Emory University researchers uncover novel self-assembly of Alzheimer’s amyloid fibrils

26.05.2003


Researchers at Emory University and Argonne National Laboratory have discovered a new method to manipulate the self-assembly and formation of amyloid fibrils, a major component of brain plaques associated with Alzheimer’s disease, thereby opening new avenues for examination of their formation and for the construction of robust nanotubes that have potential applications in research, industry and medicine.

Certain short amino acid chains, the building blocks of proteins, are capable of self-assembly into the disease-causing amyloid fibrils of Alzheimer’s. Emory biochemistry professor David Lynn and his colleagues have now enticed these amyloid peptides to self-assemble into well-defined nanotubes 15 billionths of a meter across. Such nanotubes can now serve as minute scaffolds to build nanotechnological devices with potential applications in many fields. These findings are published in the May 21 issue of the Journal of the American Chemical Society in their paper "Exploiting Amyloid Fibril Lamination for Nanotube Self-Assembly."

"We took what we know about amyloid fibril self-assembly, and used that information to construct novel, self-assembling nanotubes. The creation of these new structures will in turn teach us more about the physical properties of amyloids and the pathways to their formation, which puts us in a better position to understand why they are so damaging and cause disease," says Lynn.



The discovery underscores the potential of the emerging field of "synthetic biology," demonstrating the use of self-assembling elements that nature goes to great lengths to avoid, and converting them to new functional materials, Lynn says.

"Nature goes to extreme measures to keep these amyloids from forming, but nature still hasn’t figured out a way on its own to totally control the formation of them. What we have uncovered is a way to control and manipulate the amyloid in a way that nature can’t, so that it acts differently and takes on a new form as a self-assembling nanotube that has many applications for nanotechnology."

Lynn, Asa Griggs Candler Professor of Chemistry and Biology, works in the areas of biomolecular chemistry, molecular evolution and chemical biology. Lynn’s research in biological chemistry focuses on the spontaneous self-assembly of biological structures, including protein folding, nucleic acid assembly and the organogenesis of multicellular organisms--the basis of the energies that control self-assembly.

Lynn’s research team includes graduate student Kun Lu; Vincent Conticello, professor of biomaterials at Emory; and Jaby Jacob and Pappannan Thiyagarajan of Argonne National Laboratory.

Deb Hammacher | EurekAlert!
Further information:
http://www.emory.edu/

More articles from Health and Medicine:

nachricht Novel anti-cancer nanomedicine for efficient chemotherapy
17.09.2019 | University of Helsinki

nachricht Researchers have identified areas of the retina that change in mild Alzheimer's disease
16.09.2019 | Universidad Complutense de Madrid

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Happy hour for time-resolved crystallography

Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Hamburg and the European Molecular Biology Laboratory (EMBL) outstation in the city have developed a new method to watch biomolecules at work. This method dramatically simplifies starting enzymatic reactions by mixing a cocktail of small amounts of liquids with protein crystals. Determination of the protein structures at different times after mixing can be assembled into a time-lapse sequence that shows the molecular foundations of biology.

The functions of biomolecules are determined by their motions and structural changes. Yet it is a formidable challenge to understand these dynamic motions.

Im Focus: Modular OLED light strips

At the International Symposium on Automotive Lighting 2019 (ISAL) in Darmstadt from September 23 to 25, 2019, the Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, a provider of research and development services in the field of organic electronics, will present OLED light strips of any length with additional functionalities for the first time at booth no. 37.

Almost everyone is familiar with light strips for interior design. LED strips are available by the metre in DIY stores around the corner and are just as often...

Im Focus: Tomorrow´s coolants of choice

Scientists assess the potential of magnetic-cooling materials

Later during this century, around 2060, a paradigm shift in global energy consumption is expected: we will spend more energy for cooling than for heating....

Im Focus: The working of a molecular string phone

Researchers from the Department of Atomically Resolved Dynamics of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg, the University of Potsdam (both in Germany) and the University of Toronto (Canada) have pieced together a detailed time-lapse movie revealing all the major steps during the catalytic cycle of an enzyme. Surprisingly, the communication between the protein units is accomplished via a water-network akin to a string telephone. This communication is aligned with a ‘breathing’ motion, that is the expansion and contraction of the protein.

This time-lapse sequence of structures reveals dynamic motions as a fundamental element in the molecular foundations of biology.

Im Focus: Milestones on the Way to the Nuclear Clock

Two research teams have succeeded simultaneously in measuring the long-sought Thorium nuclear transition, which enables extremely precise nuclear clocks. TU Wien (Vienna) is part of both teams.

If you want to build the most accurate clock in the world, you need something that "ticks" very fast and extremely precise. In an atomic clock, electrons are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Society 5.0: putting humans at the heart of digitalisation

10.09.2019 | Event News

Interspeech 2019 conference: Alexa and Siri in Graz

04.09.2019 | Event News

AI for Laser Technology Conference: optimizing the use of lasers with artificial intelligence

29.08.2019 | Event News

 
Latest News

Stroke patients relearning how to walk with peculiar shoe

18.09.2019 | Innovative Products

Statistical inference to mimic the operating manner of highly-experienced crystallographer

18.09.2019 | Physics and Astronomy

Scientists' design discovery doubles conductivity of indium oxide transparent coatings

18.09.2019 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>