Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Time to Go Beyond Cholesterol, MUHC Cardiologists Suggest

28.02.2003


There is a better way to determine risk of heart disease than measuring cholesterol, according to a new study by cardiologists from the Research Institute of the McGill University Health Centre (MUHC). This study shows that measuring the amount of a protein called apoprotein B or apoB, is a more accurate and efficient test than measuring cholesterol. These findings will be published in the March issue of the international journal, The Lancet.

ôThe tradition in clinical practice is to look at the levels and ratios of cholesterol as predictors of cardiovascular disease, ö says Dr. Allan Sniderman, MUHC cardiologist and first author of the study. ôBecause this test has its limitations we decided to look at other possibilities. This study shows that apoB is a more robust indicator of a cardiac events and we suggest that it is superior to looking just at cholesterol levels.ö

Sniderman and colleagues from Australia, British Columbia, Sweden and The Netherlands, analyzed data from epidemiological studies and clinical trials involving thousands of heart patients. Their overwhelming conclusion was that, although measuring levels of cholesterol is a good start, it is not enough. ôWhen we looked at data from patients who had their cholesterol levels lowered using medications, we found that their apoB levels were still high. This suggests that these patients are still at risk of having a heart attack. This is a concern because according to the cholesterol results, the patient was adequately treated,ö says Dr. Sniderman.

Because apoproteins can be accurately and inexpensively measured in routine clinical laboratories, we suggest that this measurement should be brought into clinical practice. In addition, this test is considerably more convenient to the patients because fasting is not required, ô concludes Dr. Sniderman.

Apoproteins are specialized transport proteins that carry lipids, or fats in the blood. Most of the cholesterol in blood is present in low-density lipoprotein (LDL) particles. Each LDL particle contains one molecule of apoB, which surrounds and stabilizes it. LDL particles differ in size depending on how much cholesterol they contain. The smaller LDL particles have less cholesterol, but are associated the most with coronary artery disease and are more dangerous to have circulating in the blood than the larger LDL molecules that contain more cholesterol. An increased number of LDL particles in the blood will lead to a greater risk of heart attacks or strokes. Lowering LDL particle number is the most powerful method now available to lowering the risk of heart attacks.



For more information, please contact:
Christine Zeindler, MSc
Communications Coordinator (Research)
McGill University Health Centre Communications Services


(514) 934-1934 ext. 36419
pager: (514) 406-1577

Christine Zeindler | MUHC Communications

More articles from Health and Medicine:

nachricht New nanomedicine slips through the cracks
24.04.2019 | University of Tokyo

nachricht Sugar entering the brain during septic shock causes memory loss
23.04.2019 | Rensselaer Polytechnic Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Energy-saving new LED phosphor

The human eye is particularly sensitive to green, but less sensitive to blue and red. Chemists led by Hubert Huppertz at the University of Innsbruck have now developed a new red phosphor whose light is well perceived by the eye. This increases the light yield of white LEDs by around one sixth, which can significantly improve the energy efficiency of lighting systems.

Light emitting diodes or LEDs are only able to produce light of a certain colour. However, white light can be created using different colour mixing processes.

Im Focus: Quantum gas turns supersolid

Researchers led by Francesca Ferlaino from the University of Innsbruck and the Austrian Academy of Sciences report in Physical Review X on the observation of supersolid behavior in dipolar quantum gases of erbium and dysprosium. In the dysprosium gas these properties are unprecedentedly long-lived. This sets the stage for future investigations into the nature of this exotic phase of matter.

Supersolidity is a paradoxical state where the matter is both crystallized and superfluid. Predicted 50 years ago, such a counter-intuitive phase, featuring...

Im Focus: Explosion on Jupiter-sized star 10 times more powerful than ever seen on our sun

A stellar flare 10 times more powerful than anything seen on our sun has burst from an ultracool star almost the same size as Jupiter

  • Coolest and smallest star to produce a superflare found
  • Star is a tenth of the radius of our Sun
  • Researchers led by University of Warwick could only see...

Im Focus: Quantum simulation more stable than expected

A localization phenomenon boosts the accuracy of solving quantum many-body problems with quantum computers which are otherwise challenging for conventional computers. This brings such digital quantum simulation within reach on quantum devices available today.

Quantum computers promise to solve certain computational problems exponentially faster than any classical machine. “A particularly promising application is the...

Im Focus: Largest, fastest array of microscopic 'traffic cops' for optical communications

The technology could revolutionize how information travels through data centers and artificial intelligence networks

Engineers at the University of California, Berkeley have built a new photonic switch that can control the direction of light passing through optical fibers...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Revered mathematicians and computer scientists converge with 200 young researchers in Heidelberg!

17.04.2019 | Event News

First dust conference in the Central Asian part of the earth’s dust belt

15.04.2019 | Event News

Fraunhofer FHR at the IEEE Radar Conference 2019 in Boston, USA

09.04.2019 | Event News

 
Latest News

Proteins stand up to nerve cell regression

24.04.2019 | Life Sciences

New sensor detects rare metals used in smartphones

24.04.2019 | Life Sciences

Controlling instabilities gives closer look at chemistry from hypersonic vehicles

24.04.2019 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>