A common genetic variant influences individual responses and adaptation to pain and other stressful stimuli and may underlie vulnerability to many psychiatric and other complex diseases, reports David Goldman, M.D., Chief, Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, and colleagues at NIAAA and the University of Michigan. COMT val158met Genotype Affects m-Opioid Neurotransmitter Responses to a Pain Stressor appears in the February 21 issue of Science (299:1240, 2003).
"Emotional response to stress contributes in many drinkers to the development of alcoholism," said George Kunos, M.D., Ph.D., Scientific Director, Division of Intramural Clinical and Biological Research, NIAAA. "Dr. Goldman and his colleagues have uncovered a genetic explanation for why some individuals and groups may be especially susceptible to consuming alcohol and to increasing their consumption in response to stress."
Earlier reports by first author Jon-Kar Zubieta, M.D., Ph.D., Department of Psychiatry and Mental Health Research Institute and Department of Radiology, University of Michigan (Science 293:311, 2001) and others showed that responses to pain vary considerably from one person to another, with some of the difference in sensitivity attributable to genetic factors. Subsequent work showed that some of these effects were due to gender-related factors (Journal of Neuroscience 22:5100, 2002). For the current study, Drs. Goldman, Zubieta, and their colleagues used positron emission tomography (PET) targeting the endogenous opioid system to examine the effects of a specific genetic variant on neurochemical brain responses to sustained pain. The researchers also used questionnaires that measure pain-related sensory and affective qualities and internal emotional state to link the neurochemical responses to participants’ psychological and physical experience of the pain challenge.
Ann Bradley | EurekAlert!
Study tracks inner workings of the brain with new biosensor
16.08.2018 | Rheinische Friedrich-Wilhelms-Universität Bonn
Foods of the future
15.08.2018 | Georg-August-Universität Göttingen
New design tool automatically creates nanostructure 3D-print templates for user-given colors
Scientists present work at prestigious SIGGRAPH conference
Most of the objects we see are colored by pigments, but using pigments has disadvantages: such colors can fade, industrial pigments are often toxic, and...
Scientists at the University of California, Los Angeles present new research on a curious cosmic phenomenon known as "whistlers" -- very low frequency packets...
Scientists develop first tool to use machine learning methods to compute flow around interactively designable 3D objects. Tool will be presented at this year’s prestigious SIGGRAPH conference.
When engineers or designers want to test the aerodynamic properties of the newly designed shape of a car, airplane, or other object, they would normally model...
Researchers from TU Graz and their industry partners have unveiled a world first: the prototype of a robot-controlled, high-speed combined charging system (CCS) for electric vehicles that enables series charging of cars in various parking positions.
Global demand for electric vehicles is forecast to rise sharply: by 2025, the number of new vehicle registrations is expected to reach 25 million per year....
Proteins must be folded correctly to fulfill their molecular functions in cells. Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. The chaperone TRiC uses a previously undescribed mechanism to perform actin folding. The study was recently published in the journal Cell.
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle...
17.08.2018 | Event News
08.08.2018 | Event News
27.07.2018 | Event News
17.08.2018 | Physics and Astronomy
17.08.2018 | Information Technology
17.08.2018 | Life Sciences